Improving Voice Production for Adults With Age-related Dysphonia

NCT ID: NCT03702322

Last Updated: 2025-10-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

220 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-04-01

Study Completion Date

2026-12-30

Brief Summary

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The objectives for this research are to determine the mechanisms by which specific therapy tasks improve voice in age-related dysphonia, and the conditions that limit the extent of improvement. The central hypothesis is that targeted therapy tasks will improve voice, and that severity will determine the extent of improvement.

Detailed Description

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Conditions

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Presbylarynx Age-Related Dysphonia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

All participants receive every intervention in randomized order
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Participants in the perceptual studies rating audio and visual files will be masked.

Study Groups

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Participants

All participants will undergo each treatment.

Group Type OTHER

Voice therapy: respiratory

Intervention Type BEHAVIORAL

Abdominal voice onset

Voice therapy: glottal closure

Intervention Type BEHAVIORAL

Pulling/pushing task

Voice therapy: loud

Intervention Type BEHAVIORAL

Assertive task

Voice therapy: Semiocclusion

Intervention Type BEHAVIORAL

Semi-occluded vocal tract

Interventions

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Voice therapy: respiratory

Abdominal voice onset

Intervention Type BEHAVIORAL

Voice therapy: glottal closure

Pulling/pushing task

Intervention Type BEHAVIORAL

Voice therapy: loud

Assertive task

Intervention Type BEHAVIORAL

Voice therapy: Semiocclusion

Semi-occluded vocal tract

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Adults in age range who volunteer
* Can understand and complete directions presented in English
* People with voice disorder associated with advancing age will be included, including bowing, incomplete closure, mild edema, erythema, signs of laryngopharyngeal reflux.

Exclusion Criteria

* Laryngeal differences not related to aging (e.g., vocal fold paralysis, moderate-severe edema, lesions, leukoplakia, dysplasia, Parkinson disease)
* Known history of stroke, brain injury, or other neurological disorder
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Mayo Clinic

OTHER

Sponsor Role collaborator

University of Arizona

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robin A Samlan, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Arizona

Locations

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Mayo Clinic

Scottsdale, Arizona, United States

Site Status

University of Arizona

Tucson, Arizona, United States

Site Status

Countries

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United States

Other Identifiers

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R21DC016356

Identifier Type: NIH

Identifier Source: org_study_id

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