Impact of Whole-body Vibration Training on Sarcopenic Elderly

NCT ID: NCT03695354

Last Updated: 2021-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-02-08

Study Completion Date

2021-07-31

Brief Summary

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Sarcopenia is defined as a phenomenon which the amount of muscle mass in elderly aged 60-70 years is about 20-30% lower than that of the young adults and middle-aged people due to muscle atrophy caused by aging and alteration in muscle itself in aged skeletal muscle. Whole body vibration(WBV) training can be a choice for hospitalized patients who cannot conduct high intensity resistance training.

Detailed Description

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This study is prospective study.

The goal of this study is

1. To investigate the effect of whole body vibration training using vibration platform with tilt table on muscle mass, muscle strength, physical performance in hospitalized older adults with sarcopenia.
2. To demonstrate whether whole body vibration training using vibration platform with tilt table can be useful in hospitalized older adults with sarcopenia who could not perform high intensity exercise.

Conditions

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Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Whole body vibration plus conventional therapy group

conventional therapy + whole body vibration training for 40 minutes per day, five days per week for two-week period.

Group Type EXPERIMENTAL

whole body vibration plus conventional therapy

Intervention Type DEVICE

Subjects enrolled in whole body vibration training group are exposed to side-to-side alternating vertical sinusoidal vibration. Galileo system(Novotec Medical GmbH, Pforzheim, Germany) is used to training. Frequency of whole body vibration is 12Hz and amplitude is 4mm. After 10 minutes of vibration training, subjects rest 3 minutes. Then, additional 10 minutes of training will be given.

conventional physical therapy is consisted of passive range of motion exercise and walking exercise.

conventional training group

conventional therapy (passive range of motion exercise and walking exercise) for 40 minutes per day, five days per week for two-week period.

Group Type ACTIVE_COMPARATOR

conventional therapy

Intervention Type PROCEDURE

conventional physical therapy is consisted of passive range of motion exercise and walking exercise.

Interventions

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whole body vibration plus conventional therapy

Subjects enrolled in whole body vibration training group are exposed to side-to-side alternating vertical sinusoidal vibration. Galileo system(Novotec Medical GmbH, Pforzheim, Germany) is used to training. Frequency of whole body vibration is 12Hz and amplitude is 4mm. After 10 minutes of vibration training, subjects rest 3 minutes. Then, additional 10 minutes of training will be given.

conventional physical therapy is consisted of passive range of motion exercise and walking exercise.

Intervention Type DEVICE

conventional therapy

conventional physical therapy is consisted of passive range of motion exercise and walking exercise.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* More than 70-year old people who admitted Seoul National University hospital, Bundang.
* Deconditioning subjects with diabetics, infections, chronic lung disease, etc. who cannot walk independently due to long-term hospital care.
* Subjects who had a mobility impairment.
* Subjects who can agree voluntarily.

Exclusion Criteria

* Subjects who inserted implant due to trauma within 1\~2 months recently.
* Acute coronary syndrome.
* Uncontrolled hypertension.
* Subjects who took drugs which can affects neuromuscular system.
* Severely impaired cognition
* Subjects who cannot agree volun.tarily.
Minimum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jae-Young Lim

Professor, Department of Rehabilitation Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jae-Young Lim, Ph.D.

Role: STUDY_DIRECTOR

Seoul National University Bundang Hospital

Locations

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Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Jae-Young Lim, Ph.D.

Role: CONTACT

+821053900373

Bo-Ram Kim

Role: CONTACT

+82317877732

Facility Contacts

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Jae-Young Lim, MD, PhD

Role: primary

+82317877732

Seung-Kyu Lim, MD

Role: backup

+821096045700

References

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Verschueren SM, Bogaerts A, Delecluse C, Claessens AL, Haentjens P, Vanderschueren D, Boonen S. The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: a 6-month randomized, controlled trial. J Bone Miner Res. 2011 Jan;26(1):42-9. doi: 10.1002/jbmr.181.

Reference Type BACKGROUND
PMID: 20648661 (View on PubMed)

Santin-Medeiros F, Garatachea Vallejo N. [Musculoskeletal effects of vibration training in the elderly]. Rev Esp Geriatr Gerontol. 2010 Sep-Oct;45(5):281-4. doi: 10.1016/j.regg.2010.04.001. Epub 2010 May 23. Spanish.

Reference Type BACKGROUND
PMID: 20546975 (View on PubMed)

von Stengel S, Kemmler W, Engelke K, Kalender WA. Effect of whole-body vibration on neuromuscular performance and body composition for females 65 years and older: a randomized-controlled trial. Scand J Med Sci Sports. 2012 Feb;22(1):119-27. doi: 10.1111/j.1600-0838.2010.01126.x. Epub 2010 May 24.

Reference Type BACKGROUND
PMID: 20500555 (View on PubMed)

Kemmler W, V Stengel S, Mayer S, Niedermayer M, Hentschke C, Kalender WA. [Effect of whole body vibration on the neuromuscular performance of females 65 years and older. One-year results of the controlled randomized ELVIS study]. Z Gerontol Geriatr. 2010 Apr;43(2):125-32. doi: 10.1007/s00391-009-0074-0. Epub 2009 Oct 1. German.

Reference Type BACKGROUND
PMID: 19789832 (View on PubMed)

Pietrangelo T, Mancinelli R, Toniolo L, Cancellara L, Paoli A, Puglielli C, Iodice P, Doria C, Bosco G, D'Amelio L, di Tano G, Fulle S, Saggini R, Fano G, Reggiani C. Effects of local vibrations on skeletal muscle trophism in elderly people: mechanical, cellular, and molecular events. Int J Mol Med. 2009 Oct;24(4):503-12. doi: 10.3892/ijmm_00000259.

Reference Type BACKGROUND
PMID: 19724891 (View on PubMed)

Machado A, Garcia-Lopez D, Gonzalez-Gallego J, Garatachea N. Whole-body vibration training increases muscle strength and mass in older women: a randomized-controlled trial. Scand J Med Sci Sports. 2010 Apr;20(2):200-7. doi: 10.1111/j.1600-0838.2009.00919.x. Epub 2009 Apr 20.

Reference Type BACKGROUND
PMID: 19422657 (View on PubMed)

Kaeding TS. [Sarcopenia and whole body vibration training: an overview]. Z Gerontol Geriatr. 2009 Apr;42(2):88-92. doi: 10.1007/s00391-008-0565-4. Epub 2008 Aug 29. German.

Reference Type BACKGROUND
PMID: 18726053 (View on PubMed)

Bogaerts A, Delecluse C, Claessens AL, Coudyzer W, Boonen S, Verschueren SM. Impact of whole-body vibration training versus fitness training on muscle strength and muscle mass in older men: a 1-year randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2007 Jun;62(6):630-5. doi: 10.1093/gerona/62.6.630.

Reference Type BACKGROUND
PMID: 17595419 (View on PubMed)

Cardinale M, Rittweger J. Vibration exercise makes your muscles and bones stronger: fact or fiction? J Br Menopause Soc. 2006 Mar;12(1):12-8. doi: 10.1258/136218006775997261.

Reference Type BACKGROUND
PMID: 16513017 (View on PubMed)

Cardinale M, Wakeling J. Whole body vibration exercise: are vibrations good for you? Br J Sports Med. 2005 Sep;39(9):585-9; discussion 589. doi: 10.1136/bjsm.2005.016857.

Reference Type BACKGROUND
PMID: 16118292 (View on PubMed)

Cardinale M, Pope MH. The effects of whole body vibration on humans: dangerous or advantageous? Acta Physiol Hung. 2003;90(3):195-206. doi: 10.1556/APhysiol.90.2003.3.2.

Reference Type BACKGROUND
PMID: 14594190 (View on PubMed)

Roelants M, Delecluse C, Verschueren SM. Whole-body-vibration training increases knee-extension strength and speed of movement in older women. J Am Geriatr Soc. 2004 Jun;52(6):901-8. doi: 10.1111/j.1532-5415.2004.52256.x.

Reference Type BACKGROUND
PMID: 15161453 (View on PubMed)

Rees S, Murphy A, Watsford M. Effects of vibration exercise on muscle performance and mobility in an older population. J Aging Phys Act. 2007 Oct;15(4):367-81. doi: 10.1123/japa.15.4.367.

Reference Type BACKGROUND
PMID: 18048942 (View on PubMed)

Rees SS, Murphy AJ, Watsford ML. Effects of whole body vibration on postural steadiness in an older population. J Sci Med Sport. 2009 Jul;12(4):440-4. doi: 10.1016/j.jsams.2008.02.002. Epub 2008 Jun 11.

Reference Type BACKGROUND
PMID: 18550436 (View on PubMed)

Jordan MJ, Norris SR, Smith DJ, Herzog W. Vibration training: an overview of the area, training consequences, and future considerations. J Strength Cond Res. 2005 May;19(2):459-66. doi: 10.1519/13293.1.

Reference Type BACKGROUND
PMID: 15903391 (View on PubMed)

Cheung WH, Mok HW, Qin L, Sze PC, Lee KM, Leung KS. High-frequency whole-body vibration improves balancing ability in elderly women. Arch Phys Med Rehabil. 2007 Jul;88(7):852-7. doi: 10.1016/j.apmr.2007.03.028.

Reference Type BACKGROUND
PMID: 17601464 (View on PubMed)

Song GE, Kim K, Lee DJ, Joo NS. Whole body vibration effects on body composition in the postmenopausal korean obese women: pilot study. Korean J Fam Med. 2011 Nov;32(7):399-405. doi: 10.4082/kjfm.2011.32.7.399. Epub 2011 Nov 30.

Reference Type BACKGROUND
PMID: 22745878 (View on PubMed)

Park YG, Kwon BS, Park JW, Cha DY, Nam KY, Sim KB, Chang J, Lee HJ. Therapeutic effect of whole body vibration on chronic knee osteoarthritis. Ann Rehabil Med. 2013 Aug;37(4):505-15. doi: 10.5535/arm.2013.37.4.505. Epub 2013 Aug 26.

Reference Type BACKGROUND
PMID: 24020031 (View on PubMed)

Lee BK, Chon SC. Effect of whole body vibration training on mobility in children with cerebral palsy: a randomized controlled experimenter-blinded study. Clin Rehabil. 2013 Jul;27(7):599-607. doi: 10.1177/0269215512470673. Epub 2013 Feb 14.

Reference Type BACKGROUND
PMID: 23411791 (View on PubMed)

Smoliner C, Sieber CC, Wirth R. Prevalence of sarcopenia in geriatric hospitalized patients. J Am Med Dir Assoc. 2014 Apr;15(4):267-72. doi: 10.1016/j.jamda.2013.11.027.

Reference Type BACKGROUND
PMID: 24679831 (View on PubMed)

Patel HP, Syddall HE, Jameson K, Robinson S, Denison H, Roberts HC, Edwards M, Dennison E, Cooper C, Aihie Sayer A. Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing. 2013 May;42(3):378-84. doi: 10.1093/ageing/afs197. Epub 2013 Feb 5.

Reference Type BACKGROUND
PMID: 23384705 (View on PubMed)

Kim IH. Age and gender differences in the relation of chronic diseases to activity of daily living (ADL) disability for elderly South Koreans: based on representative data. J Prev Med Public Health. 2011 Jan;44(1):32-40. doi: 10.3961/jpmph.2011.44.1.32.

Reference Type BACKGROUND
PMID: 21483221 (View on PubMed)

Other Identifiers

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B1607354003

Identifier Type: -

Identifier Source: org_study_id

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