Strain Echocardiography During Septic Shock : an Observational Pilot Study

NCT ID: NCT03663192

Last Updated: 2025-12-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-02-22
• Study Completion Date: 2018-03-31

Brief Summary

The mortality of septic shock remains high nowadays despite a trend toward improvement.Septic cardiomyopathy has been reported in most experimental models of sepsis shock. Its relationship with mortality is unclear. A decrease in mortality have been reported in patients with decreased left ventricular ejection fraction (LVEF), but a recent meta-analysis did not support such results. In fact, it appears that high LVEF are linked to profound vasoplegia which is associated to bad outcome.

In the other hand, alterations of Strain echocardiography, a new method allowing a more sensitive evaluation of heart function, have been associated with a worse outcome in sepsis patients. Only few studies have examined echocardiographic strain during sepsis shock in human, and its natural history was only described in pigs. Moreover, the right ventricular strain was reported only by Orde et al whereas the evolution of strain during fluid infusion have never been studied. The aim of the present study is to describe the natural history of echocardiographic strain during sepsis shock and to determine its prognosis value.

Conditions

Shock, Septic; Echocardiography

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

strain echocardiography

strain echocardiography during septic shock

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Septic shock (suspected or proven infection and norepinephrine ≥ 0,25µg/kg/min)
• Inclusion within the first 24h of septic shock

Exclusion Criteria

• Patient < 18 year of age
• Pregnant women
• History of myocardial infarction, valvular disease, atrial fibrillation

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Claire Roger, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

CHU Nimes

Locations

Intensive care unit CHU Nimes

Nîmes, , France

Countries

France

References

Bazalgette F, Roger C, Louart B, Daurat A, Bobbia X, Lefrant JY, Muller L. Prognostic value and time course evolution left ventricular global longitudinal strain in septic shock: an exploratory prospective study. J Clin Monit Comput. 2021 Dec;35(6):1501-1510. doi: 10.1007/s10877-020-00620-w. Epub 2020 Nov 20.

Reference Type: RESULT

PMID: 33216237 (View on PubMed)

Other Identifiers

IRB : 16.02.07

Identifier Type: -

Identifier Source: org_study_id