Sedation Of Adult Patients Undergoing Gastrointestinal Endoscopy: A Network Meta-analysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

6963 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-02-05

Study Completion Date

2018-03-07

Brief Summary

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The objective of this study is to compare the efficacy and safety of dexmedetomidine with other sedatives in sedation during endoscopy by analyzing the most recently published interventional trials and observational studies.

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Detailed Description

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A variety of sedatives are available in procedural sedation and the efficacy \& safety have been compared in several trials for procedural sedation. However, none of clinical trial has enough number of patients to clarify the conclusive differences among sedatives. Thus, pooling all available studies together systematically by network meta-analysis for GI endoscopic procedure may provide a better understanding of efficacy and safety of sedatives. Therefore we would like to conduct a network meta-analysis to analyze the outcomes of GI endoscopy by using the most recently-published interventional trials.

Conditions

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Gastrointestinal Endoscopy Sedation Dexmedetomidine

Study Design

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Observational Model Type

OTHER

Study Time Perspective

OTHER

Study Groups

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Dexmedetomidine

Dexmedetomidine group

Dexmedetomidine

Intervention Type DRUG

Dexmedetomidine group

Midazolam

Midazolam group

Midazolam

Intervention Type DRUG

Midazolam group

propofol

propofol group

Propofol

Intervention Type DRUG

Propofol group

Midazolam/Propofol

Midazolam and Propofol group

Midazolam/Propofol

Intervention Type DRUG

Midazolam/Propofol group

Interventions

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Dexmedetomidine

Dexmedetomidine group

Intervention Type DRUG

Midazolam

Midazolam group

Intervention Type DRUG

Propofol

Propofol group

Intervention Type DRUG

Midazolam/Propofol

Midazolam/Propofol group

Intervention Type DRUG

Other Intervention Names

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The group includes patients treated with Dexmedetomidine The group includes patients treated with Midazolam The group includes patients treated with Propofol The group includes patients treated with Midazolam and propofol

Eligibility Criteria

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Inclusion Criteria

* Inclusion criteria We will include studies if they (1) the setting was using any sedative for endoscopy for an procedural sedation (2) the study compared dexmedetomidine with other sedative for sedative therapy and (3) the outcomes included satisfaction score and adverse events.

Exclusion Criteria

* Exclusion criteria We excluded studies if they (1) the number of sedative was different in two arms (2) did not report the specific results comparing dexmedetomidine with other sedatives.

Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No