Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-05

Study Completion Date

2021-11-02

Brief Summary

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This study evaluates whether adding a dietary supplement similar to coconut oil (MCT oil) to feedings in premature infants will reduce the amount of yeast (Candida) detectable in their stool. Infants who have Candida in their stool are eligible to participate. Half of the enrolled infants will have additional MCT oil added to their feedings and half will not.

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Detailed Description

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Conditions

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Candida Infection Premature Infant

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Control

This group receives no feeding supplement.

Group Type NO_INTERVENTION

No interventions assigned to this group

MCT Oil

This group is supplemented with MCT oil

Group Type EXPERIMENTAL

Medium-Chain Triglyceride (MCT) Oil

Intervention Type DRUG

Infants receive 0.5 ml/oz of MCT oil to their prescribed feedings for 21 days or until hospital discharge.

Interventions

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Medium-Chain Triglyceride (MCT) Oil

Infants receive 0.5 ml/oz of MCT oil to their prescribed feedings for 21 days or until hospital discharge.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Premature infant admitted to the Neonatal Intensive Care Unit at Women \& Infants Hospital
* Receiving full enteral feeds of either preterm or transitional formula or fortified breast milk
* Anticipated to have a minimum stay of two weeks