Comparison of Two Different Lipid Emulsions for Parenteral Nutrition in Preterm Infants

NCT ID: NCT00497289

Last Updated: 2021-03-10

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2008-02-29

Brief Summary

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The study shall provide evidence for the save and efficient use of a fish oil containing lipid emulsion in parenteral nutrition of preterm infants.Safety will be assessed by monitoring hepatological and hematological laboratory parameters. Efficiency will be assessed by monitoring of inflammatory parameters.

Detailed Description

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Conditions

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Preterm Infants Parenteral Nutrition n-3 Fatty Acids

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Lipidem 20 %

Group Type EXPERIMENTAL

Lipidem 20%

Intervention Type DRUG

daily i.v. infusion for up to 5 days

2

Lipofundin MCT/LCT 20%

Group Type ACTIVE_COMPARATOR

Lipofundin MCT/LCT 20 %

Intervention Type DRUG

daily i.v. infusion for up to 5 days

Interventions

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Lipofundin MCT/LCT 20 %

daily i.v. infusion for up to 5 days

Intervention Type DRUG

Lipidem 20%

daily i.v. infusion for up to 5 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* prematurity (birth weight 500 - 1500 g)
* postnatal age \<= 72 h
* need for cumulative parenteral energy supply of at least 70% during study duration
* signed informed consent form

Exclusion Criteria

* simultaneous participation in another clinical study
* platelet count below 50000 /ml
* cumulative enteral energy supply of \> 30 % during study duration
* serious congenital infections and/or diseases
* serious metabolic disturbances
* severe cranial bleeding (Papile III, IV)
* need for administration of blood products
* contra-indication for iv lipid administration
* withdrawal of consent
Minimum Eligible Age

5 Hours

Maximum Eligible Age

3 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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B. Braun Melsungen AG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Berthold V. Koletzko, Prof., MD

Role: PRINCIPAL_INVESTIGATOR

Dr. von Hauner Children´s Hospital, University of Munich

Locations

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Neonatology of the Pediatric University Hospital

Munich, Bavaria, Germany

Site Status

Ernst Moritz Arndt University , Childrens Hospital

Greifswald, , Germany

Site Status

Countries

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Germany

Other Identifiers

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HC-G-H-0404

Identifier Type: -

Identifier Source: org_study_id

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