Efficacy and Safety of Chuna Manual Treatment as an Adjunctive Therapy After Total Knee Arthroplasty: A Study Protocol for a Single-Center, Randomized, Assessor Blind, Parallel-Group Clinical Trial

NCT ID: NCT03625050

Last Updated: 2021-07-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-01

Study Completion Date

2021-05-31

Brief Summary

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Evaluate the efficacy and safety of Chuna treatment as an adjunctive therapy in patients with moderate pain following total knee replacement.

Detailed Description

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Conditions

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Total Knee Replacement Manipulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Chuna + Usual care

Group Type EXPERIMENTAL

Chuna + Usual care(Celecoxib and esomeprazole)

Intervention Type PROCEDURE

Chuna therapy (CT), 2 sessions/week, 4 weeks (8 sessions in total) Usual care therapy (UC, Celecoxib 200mg, qd and esomeprazole 20mg, qd), 4 weeks

Usual care consists of physical therapy, CP based medications and patients education. Physical therapy consists of meridian muscle interferential current electricity (or meridian transcutaneous electricity) and hot pack (or infrared lamp).

CT and UC group will receive the same UC regimen.

Usual care

Group Type ACTIVE_COMPARATOR

Usual care(Celecoxib and esomeprazole)

Intervention Type DRUG

Usual care therapy (UC, Celecoxib 200mg, qd and esomeprazole 20mg, qd), 4 weeks

Usual care consists of physical therapy, CP based medications and patients education. Physical therapy consists of meridian muscle interferential current electricity (or meridian transcutaneous electricity) and hot pack (or infrared lamp).

Interventions

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Chuna + Usual care(Celecoxib and esomeprazole)

Chuna therapy (CT), 2 sessions/week, 4 weeks (8 sessions in total) Usual care therapy (UC, Celecoxib 200mg, qd and esomeprazole 20mg, qd), 4 weeks

Usual care consists of physical therapy, CP based medications and patients education. Physical therapy consists of meridian muscle interferential current electricity (or meridian transcutaneous electricity) and hot pack (or infrared lamp).

CT and UC group will receive the same UC regimen.

Intervention Type PROCEDURE

Usual care(Celecoxib and esomeprazole)

Usual care therapy (UC, Celecoxib 200mg, qd and esomeprazole 20mg, qd), 4 weeks

Usual care consists of physical therapy, CP based medications and patients education. Physical therapy consists of meridian muscle interferential current electricity (or meridian transcutaneous electricity) and hot pack (or infrared lamp).

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with NRS of knee pain ≥4 during the 7 days after 3 months total knee replacement
* Patients who have agreed to trial participation and provided written informed consent

Exclusion Criteria

* Those who have been diagnosed with certain serious diseases that can cause knee pain. : tumor, infectious or inflammatory disease, etc.
* Those taking analgesics for the purpose of relieving pain, fever and inflammation within 7 days
* Those with progressive neurological deficits or with severe neurological symptoms
* Those who have other chronic conditions that may interfere with the interpretation of treatment effects or outcomes : Cardiovascular disease, kidney disease, diabetic neuropathy, dementia, epilepsy, etc.
* Those who are not fit or unsafe to chuna therapy: clotting disorders, Those receiving anticoagulant therapy, Severe diabetes patients who are at risk of infection, severe cardiovascular disease
* Those who are participating in other clinical trials
* Those who have a history of participating in other clinical trials within one month
* Those who are difficult to write a research consent form
* Those who are judged to be inappropriate for the clinical study by the researchers.
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Catholic Kwandong University

OTHER

Sponsor Role collaborator

Gachon University Gil Oriental Medical Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yun-Kyung Song

Sponsor-principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yun Kyung Song, PhD

Role: PRINCIPAL_INVESTIGATOR

Gachon university of Gil oriental hospital

Locations

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Catholic Kwandong University International St. Mary'S Hospita

Incheon, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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ISEE_2018_TKA_CN

Identifier Type: -

Identifier Source: org_study_id

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