Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis
NCT ID: NCT04423432
Last Updated: 2020-06-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
36 participants
INTERVENTIONAL
2020-01-01
2020-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Control
Lower Extremity Resistance Exercise Training
3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press (8-12 RM) leg extension (8-12 RM) Sit to stand squat (with weight) Stationary Cycling (Maximum Resistance as per patient tolerance till failure)
Home Exercise Plan
2 sets of 10 repetitions/day of
1. AROM isolated knee extension and knee flexion
2. Isometric isolated knee extension and knee flexion
3. Isometric terminal knee extension
4. Sit to stand squat
terminal extension as Home Exercise Program (HEP). (Iwamoto J et al, 2007)
Electrotherapy + Heating
Iinterferential Current therapy (2P), in combination with heating pad for 20 minutes
Joint Mobilization
1. Tibio-femoral Anterior Glide
2. Tibio-femoral Posterior Glide
3. Patellofemoral Joint Mobilization
Creatine Supplementation
Lower Extremity Resistance Exercise Training
3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press (8-12 RM) leg extension (8-12 RM) Sit to stand squat (with weight) Stationary Cycling (Maximum Resistance as per patient tolerance till failure)
Home Exercise Plan
2 sets of 10 repetitions/day of
1. AROM isolated knee extension and knee flexion
2. Isometric isolated knee extension and knee flexion
3. Isometric terminal knee extension
4. Sit to stand squat
terminal extension as Home Exercise Program (HEP). (Iwamoto J et al, 2007)
Electrotherapy + Heating
Iinterferential Current therapy (2P), in combination with heating pad for 20 minutes
Joint Mobilization
1. Tibio-femoral Anterior Glide
2. Tibio-femoral Posterior Glide
3. Patellofemoral Joint Mobilization
Creatine Supplementation
Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks
Glucoseamine/ Chondritin Sulfate Supplementation
Lower Extremity Resistance Exercise Training
3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press (8-12 RM) leg extension (8-12 RM) Sit to stand squat (with weight) Stationary Cycling (Maximum Resistance as per patient tolerance till failure)
Home Exercise Plan
2 sets of 10 repetitions/day of
1. AROM isolated knee extension and knee flexion
2. Isometric isolated knee extension and knee flexion
3. Isometric terminal knee extension
4. Sit to stand squat
terminal extension as Home Exercise Program (HEP). (Iwamoto J et al, 2007)
Electrotherapy + Heating
Iinterferential Current therapy (2P), in combination with heating pad for 20 minutes
Joint Mobilization
1. Tibio-femoral Anterior Glide
2. Tibio-femoral Posterior Glide
3. Patellofemoral Joint Mobilization
Glucoseamine/ Chondritin Sulfate Supplementation
Glucoseamine/ Chondritin Sulfate Supplementation (500mg+400mg/day)
Interventions
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Lower Extremity Resistance Exercise Training
3 times supervised exercise for 4 weeks Warm up (Self Paced walking for 10 minutes) leg press (8-12 RM) leg extension (8-12 RM) Sit to stand squat (with weight) Stationary Cycling (Maximum Resistance as per patient tolerance till failure)
Home Exercise Plan
2 sets of 10 repetitions/day of
1. AROM isolated knee extension and knee flexion
2. Isometric isolated knee extension and knee flexion
3. Isometric terminal knee extension
4. Sit to stand squat
terminal extension as Home Exercise Program (HEP). (Iwamoto J et al, 2007)
Electrotherapy + Heating
Iinterferential Current therapy (2P), in combination with heating pad for 20 minutes
Joint Mobilization
1. Tibio-femoral Anterior Glide
2. Tibio-femoral Posterior Glide
3. Patellofemoral Joint Mobilization
Creatine Supplementation
Creatine Supplementation 20g/day for 1 week followed by 5 g/day for 3 weeks
Glucoseamine/ Chondritin Sulfate Supplementation
Glucoseamine/ Chondritin Sulfate Supplementation (500mg+400mg/day)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Knee OA with history not less than three months.
* Radiological evidences of grade III or less on Kellgren classification.
* Knee pain on VNRS no more than 8/10
Exclusion Criteria
* Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection).
* History of trauma or fractures in lower extremity.
* Signs of lumbar radiculopathy or myelopathy.
* History of knee surgery or replacement.
* Patients on intra-articular steroid therapy within two months before the commencement of the study.
* Impaired skin sensation.
* Impaired renal function
40 Years
70 Years
ALL
No
Sponsors
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Isra University
OTHER
Foundation University Islamabad
OTHER
Responsible Party
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Principal Investigators
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Muhammad Osama, PhD*
Role: PRINCIPAL_INVESTIGATOR
Foundation University Institute of Rehabilitation Sciences
Locations
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Foundation University Institute of Rehabilitation Sciences
Islamabad, Federal, Pakistan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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FUI/CTR/2020/4
Identifier Type: -
Identifier Source: org_study_id
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