MedDataX Logo

Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and Manual Therapy in Patients With Knee Osteoarthritis

NCT ID: NCT04654871

Last Updated: 2020-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-11-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Osteoarthritis (OA) IS one of the most common joint disorders, affecting not only the joints but also the surrounding muscles, which become weak. Resistance exercise reduces pain and improves function in patients with OA of the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used by patients with OA to reduce pain and thereby maintain the ability to perform daily activities. However, there is accumulating evidence for a negative effect of NSAIDs, thus many patients with OA are treated with dietary supplementations such as glucosamine and chondroitin sulfate, and some studies show a beneficial effects on cartilage and pain. However, their effect on OA symptoms and cartilage remains controversial. Thus, it is important to investigate whether a potentially beneficial effect of glucosamine and chondroitin sulfate with resistance exercise and manual therapy in patients with knee OA.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Osteoarthritis Osteoarthritis, Knee

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

chondroitin sulfate resistance exercise strength training manual therapy glucosamine joint mobilization

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Experimental Group

Group Type EXPERIMENTAL

Chondroitin Sulfate

Intervention Type DIETARY_SUPPLEMENT

Glucosamine 500 mg Chondroitin sulfate sodium 400mg 3/day

Resistance exercise training

Intervention Type PROCEDURE

Treadmill walking 5-10 min for warm up Strength training: (80% of 8RM)

Supervised exercise thrice a week and Home Exercise 4 times a week Leg press knee extension Knee flexion Terminal knee extension Mini squats 3 sets 8 reps 10-15 s rep rest interval 1-2 min set rest interval

Manual therapy / Joint Mobilization

Intervention Type PROCEDURE

Ant. tib-fem glide Post tib-fem glide thrice a week Pattelo-femoral joint mobilization

THE therapy

Intervention Type PROCEDURE

Interferential and Heating for 20 min

Active Comparator Group

Group Type EXPERIMENTAL

Resistance exercise training

Intervention Type PROCEDURE

Treadmill walking 5-10 min for warm up Strength training: (80% of 8RM)

Supervised exercise thrice a week and Home Exercise 4 times a week Leg press knee extension Knee flexion Terminal knee extension Mini squats 3 sets 8 reps 10-15 s rep rest interval 1-2 min set rest interval

Manual therapy / Joint Mobilization

Intervention Type PROCEDURE

Ant. tib-fem glide Post tib-fem glide thrice a week Pattelo-femoral joint mobilization

THE therapy

Intervention Type PROCEDURE

Interferential and Heating for 20 min

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Chondroitin Sulfate

Glucosamine 500 mg Chondroitin sulfate sodium 400mg 3/day

Intervention Type DIETARY_SUPPLEMENT

Resistance exercise training

Treadmill walking 5-10 min for warm up Strength training: (80% of 8RM)

Supervised exercise thrice a week and Home Exercise 4 times a week Leg press knee extension Knee flexion Terminal knee extension Mini squats 3 sets 8 reps 10-15 s rep rest interval 1-2 min set rest interval

Intervention Type PROCEDURE

Manual therapy / Joint Mobilization

Ant. tib-fem glide Post tib-fem glide thrice a week Pattelo-femoral joint mobilization

Intervention Type PROCEDURE

THE therapy

Interferential and Heating for 20 min

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* knee osteoarthritis for at least 3 months
* knee pain no more than 8/10
* Grade III or less on radiograph (Kellgren classification)

Exclusion Criteria

* Malignancy
* Any additional Inflammatory disorders
* Infection
* Knee trauma
* lower limb fracture
* Lumbar radiculopathy or myelopathy
* knee surgery or replacement
* Intra-articular steroid therapy in the last 2 months
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Foundation University Islamabad

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Foundation University Institute of Rehabilitation Sciences.

Islamabad, Federal, Pakistan

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Pakistan

References

Explore related publications, articles, or registry entries linked to this study.

Osama M, Babur MN, Siddiqi FA, Tassadaq N, Arshad Tareen MA. Effects of glucosamine and chondroitin sulfate supplementation in addition to resistance exercise training and manual therapy in patients with knee osteoarthritis: A randomized controlled trial. J Pak Med Assoc. 2022 Jul;72(7):1272-1277. doi: 10.47391/JPMA.2444.

Reference Type DERIVED
PMID: 36156542 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

FUI/CTR/2020/11

Identifier Type: -

Identifier Source: org_study_id