Efficacy of Ultrasound-Guided Genicular Nerve Block in Patients With Gonarthrosis: A Randomized, Placebo-Controlled, Double-Blind Study
NCT ID: NCT07326098
Last Updated: 2026-01-08
Study Results
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Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2025-11-01
2026-12-01
Brief Summary
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In the first group, ultrasound-guided genicular nerve block will be performed using a combination of lidocaine and triamcinolone hexacetonide injection (4 mL Priloc 2% + 1 mL Artropan 20 mg). In the second group, a placebo injection (5 mL saline solution) will be administered. Both groups will be instructed to follow an appropriate exercise program after the treatment.
Patients will undergo a detailed physical examination, 6-minute walk test, VAS pain score, WOMAC questionnaire, and 3D kinematic gait analysis with pressure parameters evaluated by a blinded researcher. Evaluations will take place before treatment, 1 hour after treatment, and 1 month post-treatment.
The collected data will be analyzed for differences between the two groups and changes over time. The potential positive effects of the treatment will be measured and compared with the placebo group to assess the therapeutic efficacy.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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İntervention group
Ultrasound-guided genicular nerve block will be performed using a combination of 4 mL Priloc 2% (lidocaine) and 1 mL Artropan 20 mg (triamcinolone hexacetonide).
The syringe's outer part will be covered by an independent researcher to conceal the contents.
All participants will also perform a home exercise program: quadriceps strengthening and knee isometric exercises.
genicular nerve block
Genicular nerve block performed with pharmacological agents under ultrasound guidance is minimally invasive compared to other block techniques. It can be carried out in an outpatient setting with attention to sterility, does not involve radiation, does not require procedural surgical preparations, and is less costly both for the patient and the healthcare system. Furthermore, it has fewer side effects, with many studies reporting no side effects at all.
Placebo group
A placebo injection with 5 mL saline solution will be administered under the same sterile and ultrasound-guided conditions.
The syringe's outer part will be covered by an independent researcher to conceal the contents.
All participants will also perform a home exercise program: quadriceps strengthening and knee isometric exercises.
Placebo injection (normal saline)
A placebo injection with 5 mL saline solution will be administered under the same sterile and ultrasound-guided conditions as the active group.
The syringe will be covered by an independent researcher to conceal the contents, ensuring identical appearance across groups.
All participants will also perform a home exercise program: quadriceps strengthening and knee isometric exercises.
Interventions
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genicular nerve block
Genicular nerve block performed with pharmacological agents under ultrasound guidance is minimally invasive compared to other block techniques. It can be carried out in an outpatient setting with attention to sterility, does not involve radiation, does not require procedural surgical preparations, and is less costly both for the patient and the healthcare system. Furthermore, it has fewer side effects, with many studies reporting no side effects at all.
Placebo injection (normal saline)
A placebo injection with 5 mL saline solution will be administered under the same sterile and ultrasound-guided conditions as the active group.
The syringe will be covered by an independent researcher to conceal the contents, ensuring identical appearance across groups.
All participants will also perform a home exercise program: quadriceps strengthening and knee isometric exercises.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Diagnosis of gonarthrosis with Grade 2 or higher tibiofemoral osteoarthritis detected on plain radiographs
* Patients aged 50 years and older
* Continued pain despite conservative treatment (exercise, simple analgesics such as paracetamol, or nonsteroidal anti-inflammatory drugs)
Exclusion Criteria
* Signs of inflammation/exacerbation
* Infection at the injection site or skin lesions
* Diagnosis of malignancy
* Gait impairment (the patient must be able to ambulate independently)
* Known allergy to study medications
* Previous knee surgery
* Uncontrolled comorbid conditions such as diabetes mellitus or hypertension, which contraindicate corticosteroid use
50 Years
ALL
No
Sponsors
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Ege University
OTHER
Responsible Party
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Ece Cinar
Assistant Professor
Principal Investigators
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Ece Cinar, Assistant Professor
Role: PRINCIPAL_INVESTIGATOR
EGE UNİVERCİTY
Locations
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Ege University Faculty of Medicine
Izmir, Bornova, Turkey (Türkiye)
Ege University Faculty of Medicine
Izmir, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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References
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Lebleu J, Fonkoue L, Bandolo E, Fossoh H, Mahaudens P, Cornu O, Detrembleur C. Lower limb kinematics improvement after genicular nerve blockade in patients with knee osteoarthritis: a milestone study using inertial sensors. BMC Musculoskelet Disord. 2020 Dec 7;21(1):822. doi: 10.1186/s12891-020-03836-8.
Other Identifiers
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25-5.1/20
Identifier Type: -
Identifier Source: org_study_id
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