Metabolic Syndrome in Early Onset Versus Late Onset Vitiligo

NCT ID: NCT03622320

Last Updated: 2025-04-24

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-07-01
• Study Completion Date: 2019-06-30

Brief Summary

This study aims at detection of possible associated metabolic syndrome with vitiligo and assessment of possible contribution of the age of onset of vitiligo.

Detailed Description

This study aims at detection of incidence of metabolic syndrome in vitiligo patients and possible contribution of the age of onset of the disease. This involves detection of waist circumference, body mass index, index of central obesity, systolic and diastolic arterial blood pressure, fasting blood sugar, high density lipoproteins and triglycerides, in addition to insulin resistance as Homeostatic Model Assessment- insulin resisitance (HOMA-IR) and serum leptin in vitiligo patients. The outcomes will be correlated to extent/ severity/duration/ activity of vitiligo as well as to the age of onset. This is assumed to be of profound impact on vitiligo patients by properly assessing these patients for associated metabolic risk factors and helping prevent such metabolic derangements by detection of possible contributing factors such as insulin resistance and high serum adipokines as leptin.

Since there is temporal relation between nutrition, metabolic derangements and skin diseases where nutritional deficiencies as minerals, vitamins and fatty acids can lead to cutaneous manifestations and , on the other hand; skin diseases could contribute to metabolic derangements and nutritional deficiencies, the investigator's study will focus on nutrition and dietary habits and there possible contribution to any associated metabolic risk in vitiligo patients.

This is likely to open new horizons in the management of vitiligo, possibly through control of metabolic syndrome risk factors and insulin resistance as well as revealing possible temporal relation to dietary habits that are overlooked in vitiligo patients.

Conditions

Metabolic Syndrome; Vitiligo

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Vitiligo patients

Vitiligo patients (100 NSV and 50 segmental) who will be further classified according to age of onset and blood sample will be taken

Blood sample

Intervention Type: OTHER

Blood sample for fasting blood sugar (FBS), High density lipoproteins (HDL), Triglycerides (TG) ,HOMA-IR, serum leptin

controls

Matching will be done taking into consideration age, sex, education and socio economic status, blood sample will be taken

Blood sample

Intervention Type: OTHER

Blood sample for fasting blood sugar (FBS), High density lipoproteins (HDL), Triglycerides (TG) ,HOMA-IR, serum leptin

Interventions

Blood sample

Blood sample for fasting blood sugar (FBS), High density lipoproteins (HDL), Triglycerides (TG) ,HOMA-IR, serum leptin

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Both genders
• Patients with non-segmental vitiligo (NSV) and segmental vitiligo

Exclusion Criteria

• Smoking
• Pregnancy
• Systemic steroid intake in the last 6 months

• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Rania Mogawer

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Samar El-Tahlawi, MD

Role: PRINCIPAL_INVESTIGATOR

Cairo university, dermatology department

Locations

Cairo university hospitals, dermatology outpatient clinic

Cairo, , Egypt

Countries

Egypt

References

Ibrahim S, El-Tahlawi S, Mogawer RM, El Ansary M, Esmat S, El-Hawary M. Different vitiligo characteristics as predictors of increased risk of metabolic syndrome and insulin resistance: A case-control study. J Cosmet Dermatol. 2022 Dec;21(12):7170-7177. doi: 10.1111/jocd.15446. Epub 2022 Oct 25.

Reference Type: DERIVED

PMID: 36208004 (View on PubMed)

Other Identifiers

Vitiligo & Metabolic syndrome

Identifier Type: -

Identifier Source: org_study_id