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The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

NCT ID: NCT02309424

Last Updated: 2014-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2014-12-31

Brief Summary

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This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2 diabetes, using the arteriovenous difference technique.

Detailed Description

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Subjects with IGT or type 2 diabetes will be randomised to consume 20ml vinegar (6% acetic acid) or placebo before a mixed meal. Plasma samples will be taken for 300min from the radial artery and from a forearm vein for measurements of glucose, insulin, triglycerides, non-esterified fatty acids (NEFA) and glycerol. Muscle blood flow will be measured with strain-gauge plethysmography. Glucose flux will be calculated as the arteriovenous difference of glucose multiplied by the blood flow rates.

Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Study Groups

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Vinegar

0,50mmol vinegar (6% acetic acid)

Group Type ACTIVE_COMPARATOR

Vinegar

Intervention Type DIETARY_SUPPLEMENT

0,50mmol vinegar (6% acetic acid)

Placebo

50 ml water

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

50 ml water

Interventions

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Vinegar

0,50mmol vinegar (6% acetic acid)

Intervention Type DIETARY_SUPPLEMENT

Placebo

50 ml water

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Subjects with impaired glucose tolerance or newly diagnosed type 2 diabetes before the initiation of medication therapy
2. Recreationally active
3. With stable body weight and diet during the last two months.

Exclusion Criteria

1. Any systemic disease (besides glucose abnormalities)
2. Any medication therapy
3. Diabetic complications
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hellenic National Diabetes Center

OTHER

Sponsor Role collaborator

Attikon Hospital

OTHER

Sponsor Role lead

Responsible Party

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Panayota Mitrou

Senior Researcher, MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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George D Dimitriadis, Professor

Role: STUDY_DIRECTOR

Attikon Hospital

References

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Mitrou P, Petsiou E, Papakonstantinou E, Maratou E, Lambadiari V, Dimitriadis P, Spanoudi F, Raptis SA, Dimitriadis G. Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes. J Diabetes Res. 2015;2015:175204. doi: 10.1155/2015/175204. Epub 2015 May 6.

Reference Type DERIVED
PMID: 26064976 (View on PubMed)

Other Identifiers

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167/11-06-08

Identifier Type: -

Identifier Source: org_study_id