Investigation of the Glycemic Index of Ethiopian Honey

NCT ID: NCT02488018

Last Updated: 2016-12-28

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-06-30
• Study Completion Date: 2016-02-29

Brief Summary

The purpose of this study is to determine which of the Ethiopian honeys slowly/rapidly raise the blood glucose level.

Detailed Description

Addis Ababa University, College of Natural Sciences, Research Institutional Review Board (IRB) approved this study. Written consent forms were obtained from all 14 volunteers (7 females and 7 males). The subjects were randomly recruited from twenty eight 3rd year Food Science and Postharvest Technology students. People volunteering to participate in the study were excluded if they are: overweight, dieting, smoking, a family history of diabetes, pregnant, metabolic disorders, suffering from any illness or food allergy and regularly taking medication. The participants were checked for glucose tolerance according to the WHO (World Health Organization) classification (fasting glucose <7 mmol/L(millimole per lite) and 2-hour blood glucose concentration after a 25g glucose load <7.8 mmol/L). Ten (5 females and 5 males) were selected from fourteen using lottery sampling methods. Reference glucose and monofloral honeys were used as experimental foods. To determine the GI value, 25 grams of available carbohydrate was fed for ten healthy people in the morning after they have fasted for 11 hours overnight. After fasting blood sample was obtained. The study participants were consumed each honey and reference glucose served. Additional blood samples were taken at 15, 30, 45, 60, 90 and 120 minutes after eating commenced. Blood glucose response (Area under the curve, AUCt) for test food was compared to the blood glucose response of reference glucose (AUCr). AUC was calculated using SAS (Statistical Analysis Software), 2002. Glycemic index (GI) was calculated using:

GI= AUCt/AUCr*100

Where:

AUCt = Area Under the Curve for honey; AUCr = Area Under the Curve for the reference glucose

Conditions

Hyperglycemia, Postprandial

Keywords

Glycemic index; honey; reference glucose

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

Provision of experimental honeys

Eight experimental monofloral honeys and reference glucose

Group Type: EXPERIMENTAL

Provision of experimental honey

Intervention Type: BIOLOGICAL

Acacia, Becium grandiflorum, Croton macrostachys, Eucalyptus globules, Hypoestes, Leaucas abyssinica, Schefflera abyssinica, Syzygium guineense and reference glucose were used as test food.

25g available carbohydrate of the test food was provided to ten human subjects after fasted for 11 hours overnight.

Interventions

Provision of experimental honey

Acacia, Becium grandiflorum, Croton macrostachys, Eucalyptus globules, Hypoestes, Leaucas abyssinica, Schefflera abyssinica, Syzygium guineense and reference glucose were used as test food.

25g available carbohydrate of the test food was provided to ten human subjects after fasted for 11 hours overnight.

Intervention Type: BIOLOGICAL

Other Intervention Names

Honey Glycemic Index

Eligibility Criteria

Inclusion Criteria

• Clinical diagnosis of diabetes Disease
• Must be able to drink the honeys and reference glucose

Exclusion Criteria

• Overweight, dieting, smoking, a family history of diabetes, pregnant, metabolic disorders, suffering from any illness or food allergy and regularly taking medication.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 24 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Addis Ababa University

OTHER

Sponsor Role: lead

Responsible Party

Abera Belay

PhD Candidate

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Abera Belay, PhDCandidate

Role: PRINCIPAL_INVESTIGATOR

Addis Ababa University

Gulelat Haki, Professor

Role: STUDY_CHAIR

Department of Food Science and Technology, Botswana College of Agriculture, University of Botswana.

Kaleab Baye, Asst Prof.

Role: STUDY_CHAIR

Addis Ababa University

Samuel Melaku, Assoc Prof.

Role: STUDY_CHAIR

Columbus State University

Other Identifiers

Honey-1

Identifier Type: -

Identifier Source: org_study_id