Ultrasonographic Assessment of the Effect of CPB Acute Lung Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-20

Study Completion Date

2018-12-05

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study is designed to use the lung ultrasound to assess the effect of intermittent lung recruitment during cardiopulmonary bypass in cardiac surgeries on extra vascular lung water.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Fluid Management Guided by Pulse Pressure Variation Vs Central Venous Pressure on Lung Water Assessed by Lung Ultrasound During Liver Transplantation

NCT03243526

Lung; Congestive Liver Transplantation

COMPLETED NA

Investigation of the Effectiveness of Lung Ultrasonography in Intraoperative Fluid Management

NCT06965634

Intraoperative Fluid Management

NOT_YET_RECRUITING

Trans Alveolar Pressure Measurement as an Index for Lung Recruitment.

NCT04168151

Hypoxia

COMPLETED NA

Lung Overdistension and Abdominal Pressure Rise

NCT06174636

Respiratory Failure Respiratory Distress Syndrome, Adult

RECRUITING NA

Lung Ultrasonography and Extravascular Lung Water

NCT03085862

Extravascular Lung Water

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Significant respiratory dysfunction is a common problem after cardiac surgery, with an incidence of about 25%. the formation of atelectasis appears to be the primary factor responsible for increased intrapulmonary shunt after cardiac surgery with CPB. The investigators will use the lung ultrasound to evaluate the effects of intermittent recruitment of the lungs during CPB on extra vascular lung water (EVLW).

Objectives :

To evaluate the effect of intermittent lung recruitment during CPB in cardiac surgery on:

Lung ultrasound score (LUS),Oxygenation at different times postoperatively,Time for extubation and length of ICU stay

sixty patients aged from 18-60 years old, scheduled for elective cardiac surgery with CPB will be included in the study. Patients will be randomly allocated into one of two groups: Group A (n=30): will receive intermittent lung recruitment during CPB.Group B (n=30): control group.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Lung Ultrasound

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

sixty patients aged from 18-60 years old, scheduled for elective cardiac surgery with CPB will be included in the study. Patients will be randomly allocated into one of two groups: Group A (n=30): will receive intermittent lung recruitment during CPB.Group B (n=30): control group.

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Investigators

numbered, sealed opaque envelope.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

recruitment group

will receive intermittent lung recruitment during CPB

Group Type ACTIVE_COMPARATOR

lung recruitment

Intervention Type PROCEDURE

During bypass, patients in this group will receive a lung protective design in the form of continuous positive airway pressure (CPAP) by closing APL valve at pressure of 5 Cm H2o combined with intermittent recruitment by sustained manual lung inflation at a pressure of 35 cmH2O for 30 seconds every (30-40) minute

control group

will recieve no intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

lung recruitment

During bypass, patients in this group will receive a lung protective design in the form of continuous positive airway pressure (CPAP) by closing APL valve at pressure of 5 Cm H2o combined with intermittent recruitment by sustained manual lung inflation at a pressure of 35 cmH2O for 30 seconds every (30-40) minute

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients aged (18-60 years),
* elective valvular cardiac surgery with cardiopulmonary bypass (CPB).

Exclusion Criteria

* • Emergency surgeries.

* coronary artery bypass graft surgery
* patients requiring re-exploration in the immediate postoperative period (within 2hours)
* left Ventricular ejection fraction less than 40%
* patients with preoperative congestive heart failure, cardiogenic shock , preoperative pulmonary edema
* pre-existing severe chronic pulmonary dysfunction (defined as pulmonary disease requiring home oxygen therapy or causing shortness of breath after 1 to 2 flights of stairs)
* Morbid obesity
* Renally impaired patients with creatinine more than 2 mg/dl

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes