Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

NCT ID: NCT03616002

Last Updated: 2021-02-04

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 58 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-01-01
• Study Completion Date: 2020-03-31

Brief Summary

The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.

Detailed Description

The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.

Conditions

Hookah Smoking

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Hookah smoking

Healthy habitual Hookah smokers will undergo brachial artery flow mediated dilation, reactive hyperemia peripheral arterial tonometry or pulse tonometry before and after Hookah smoking.

Group Type: EXPERIMENTAL

Hookah smoking

Intervention Type: OTHER

ad lib hookah smoking for 30 minutes in a controlled laboratory environment.

Interventions

Hookah smoking

ad lib hookah smoking for 30 minutes in a controlled laboratory environment.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 18 to 29 years of age
• Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
• Have not smoked cigarettes within the past 12 months

Exclusion Criteria

• History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
• Exhaled carbon monoxide level >10 ppm
• BP < 140/90 mmHg
• BMI <18.5 or > 30 kg•m2
• Resting heart rate > 100 beats/min
• Taking prescription medication
• History of illicit drug use
• Pregnant

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 29 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of California, Los Angeles

OTHER

Sponsor Role: collaborator

University of California, San Francisco

OTHER

Sponsor Role: collaborator

Cedars-Sinai Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Florian Rader

M.D, M.Sc.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Florian Rader, MD

Role: PRINCIPAL_INVESTIGATOR

Cedars-Sinai Medical Center

Locations

Cedars-Sinai Medical Center

Los Angeles, California, United States

Countries

United States

References

Rezk-Hanna M, Mosenifar Z, Benowitz NL, Rader F, Rashid M, Davoren K, Moy NB, Doering L, Robbins W, Sarna L, Li N, Chang LC, Elashoff RM, Victor RG. High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults. Circulation. 2019 May 7;139(19):2215-2224. doi: 10.1161/CIRCULATIONAHA.118.037375.

Reference Type: DERIVED

PMID: 30764644 (View on PubMed)

Other Identifiers

Pro00036547

Identifier Type: -

Identifier Source: org_study_id