The Effect of Acute Mild Dehydration on Blood Pressure Control

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-08

Study Completion Date

2019-06-13

Brief Summary

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The goal of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition.

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Detailed Description

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The purpose of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. Additionally, we will determine whether or not the sympathetic nervous system has a role in mediating blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition. This will allow for a within participant comparison. Additionally, we will later determine if age alters blood pressure control at rest or during static exercise.

Conditions

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Mild Dehydration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Normal Hydration and Dehydration

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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Normal hydration then dehydration

Participants will consume water to maintain proper hydration for three days prior to testing (visit 1). Seven to 60 days later, participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 2).

Group Type EXPERIMENTAL

Normal hydration

Intervention Type OTHER

see description in 'arms'

Dehydration

Intervention Type OTHER

see description in 'arms'

Dehydration than normal hydration

Participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 1). Seven to 60 days later, participants will consume water to maintain proper hydration for three days prior to testing (visit 2).

Group Type EXPERIMENTAL

Normal hydration

Intervention Type OTHER

see description in 'arms'

Dehydration

Intervention Type OTHER

see description in 'arms'

Interventions

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Normal hydration

see description in 'arms'

Intervention Type OTHER

Dehydration

see description in 'arms'

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

• age: 20-35 years old

* age: 60-75 years old
* ECG within normal limits
* screening blood panel within normal limits

Exclusion Criteria

* high blood pressure (\>140/90 mmHg)
* history of cardiovascular disease
* history of cancer
* history of diabetes
* history of kidney disease
* obesity (BMI \> 30 kg/m2)
* smoking or tobacco use
* current pregnancy
* nursing mothers
* communication barriers

* high blood pressure (\>140/90 mmHg)
* history of cardiovascular disease
* history of cancer
* history of diabetes
* history of kidney disease
* obesity (BMI \> 30 kg/m2)
* smoking or tobacco use
* current pregnancy
* nursing mothers
* communication barriers

Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes