Hypertension Chronobiome

NCT ID: NCT03598894

Last Updated: 2026-01-23

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-07-16
• Study Completion Date: 2028-05-31

Brief Summary

Hypertension is a common condition with a concomitant burden of stroke, kidney disease and myocardial infarction. Its prevalence in developed societies is increasing as they age, and in less developed countries, as their populations assume aspects of the Western diet and lifestyle. Nocturnal non-dipping hypertension (NDHT) - the failure of blood pressure (BP) to dip at night - is estimated to complicate ~40% of hypertensives and is associated with poor outcomes. Randomized controlled trials have shown that a reduction of daytime systolic blood pressure by as little as 5mmHg on average (towards a target of 140mmHg) translates into a measurable clinical benefit. The peak nocturnal difference may be ~15-20mmHg systolic, illustrating the substantial potential for incremental benefit by adequate blood pressure control across the 24 hour cycle in this population. In this study, the investigators wish (i) to establish through repeated assessment, the stability of the non-dipping phenotype (Phase 1), and (ii) to deeply phenotype non-dippers by using parameters assessing day/night patterns, the chronobiome (Phase 2). To facilitate data collection over the course of the study, the investigators use wearable devices and mobile phone applications.

Conditions

Hypertension

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Case NDHT

Healthy non-dipping hypertensives 'NDHT' (24h mean wake SBP \>145mmHg at baseline and a decline of \<10% between mean day time and night time systolic pressures)

Ambulatory blood pressure measurements

Intervention Type: OTHER

Blood pressure will be assessed with ambulatory blood pressure measurements over the course of a day to discern day/night differences

Control NT

matched healthy normotensives 'NT' (24h mean wake SBP \<120mmHg)

Ambulatory blood pressure measurements

Intervention Type: OTHER

Blood pressure will be assessed with ambulatory blood pressure measurements over the course of a day to discern day/night differences

Control DHT

matched dipping hypertensives 'DHT' (24h mean wake SBP \>145mmHg and a decline of \>10% between mean day time and night time systolic pressures)

Ambulatory blood pressure measurements

Intervention Type: OTHER

Blood pressure will be assessed with ambulatory blood pressure measurements over the course of a day to discern day/night differences

Interventions

Ambulatory blood pressure measurements

Blood pressure will be assessed with ambulatory blood pressure measurements over the course of a day to discern day/night differences

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. >18 years of age,

2. Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,

3. 24h mean wake SBP >145mmHg at baseline from 24hr-ABPM readings within the past 12 months,

4. Decline of <10% between mean day time and night time systolic pressures quantified per 24hr-ABPM within the past 6 months,

5. Own a smartphone.

Inclusion Cohort 1 (case): non-dipping hypertensives 'NDHT'

1. >18 years of age,

2. Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,

3. 24h mean wake SBP >145mmHg from 24hr-ABPM readings confirmed per data base query within the past 12 months prior to enrollment into Phase 1 and across two subsequent 24hr-ABP sessions during Phase 1,

4. Decline of <10% between mean day time and night time systolic pressures from 24hr-ABPM readings confirmed per data base query within the past 12 months prior to enrollment into Phase 1 and across two subsequent 24hr-ABP sessions during Phase 1,

5. Own a smartphone.

Inclusion Cohort 2 (control): matched healthy normotensives 'NT'

1. >18 years of age,

2. Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,

3. Healthy (as assessed by health history, physical exam and screening lab work),

4. 24h mean wake SBP <130mmHg quantified per 24hr-ABPM,

5. Own a smartphone. 4.3.3 Inclusion Cohort 3 (control): matched dipping hypertensives 'DHT'

1) >18 years of age, 2) Upper arm with intact skin, i.e. without areas of breached or injured skin visible, for ABP measurements,

1. 24h mean wake SBP >145mmHg from 24hr-ABPM readings,

2. Decline of >10% between mean day time and night time systolic pressures from 24hr-ABPM readings,

3. Own a smartphone.

Exclusion Criteria

1. Known history of severe psychiatric or cognitive conditions, for example mania, schizophrenia, or mental retardation.

2. Shift work, defined as recurring work between 22:00-05:00,

3. History of clinically significant obstructive sleep apnea;

4. Urine creatinine > 1.5 mg/dl in men or >1.3 mg/del in women,

5. Significant liver disease (>3x upper limit of normal),

6. Diabetes mellitus,

7. Transmeridian travel across ≥2 time zones in the month prior to ABP sessions,

8. Planned transmeridian travel across more than ≥2 time zones during the planned study activities;

9. > 2 drinks of alcohol per day;

10. Use of illicit drugs which affect blood pressure;

11. Use of pacemaker or implantable Cardioverter Defibrillator, (ICD);

12. Bilateral mastectomy;

13. Hypotension, defined as 90/60 mmHg assessed during the screening visit from ≥ 3 in-office measurements initiated after 10 minutes in seated upright position with 5 minute intervals between measurements;

14. History of Raynaud's phenomenon;

15. Known allergy against natural latex rubber (contained in ABP bladder and tubing);

16. Nursing or pregnant females.

1. History of severe psychiatric illness or cognitive conditions, for example ( mania, schizophrenia, or mental retardation;

2. Shift work, defined as recurring work between 22:00-05:00;

3. Clinically significant obstructive sleep apnea as assessed per WatchPAT device;

4. Urine creatinine > 1.5 mg/dl in men or >1.3 mg/del in women;

5. Significant liver disease (>3x upper limit of normal);

6. Diabetes mellitus;

7. Past diagnosis of gastroesophageal reflux disease,

8. Transmeridian travel across ≥2 time zones in the two weeks before the 48hr deep phenotype sessions;

9. Frequent transmeridian flyer (≥2 flights per month) across more than ≥2 time zones during the 12 months of study activities;

10. Use of oral or intravenous antibiotics in the 6 months prior to enrollment;

11. Any contraindication listed below in the separate paragraph "Contraindications for the use of CorTemp® Disposable Temperature Sensors";

12. Subjects, who have received an experimental drug, used an experimental medical device within 30 days prior to screening, or who gave a blood donation of ≥ one pint within 8 weeks prior to screening;

13. > 2 drinks of alcohol per day;

14. Use of illicit drugs which affect blood pressure;

15. Nursing or pregnant (pregnancy will be repeatedly assessed at the beginning of each of the four inpatient visits, i.e. prior to the start of blood draws);

16. Use of pacemaker or implantable Cardioverter Defibrillator, (ICD)

17. Bilateral mastectomy;

18. Hypotension, defined as 90/60 mmHg assessed during the screening visit from ≥ 3 in-office measurements initiated after 10 minutes in seated upright position with 5 minute intervals between measurements;

19. History of Raynaud's phenomenon;

20. Known allergy against natural latex rubber (contained in ABP bladder and tubing);

21. Subjects taking medication with alpha-blockers;

22. History of clinically significant arrhythmias;

23. Subjects with a history of being particularly susceptible to vomiting or nausea;

24. BMI ≥ 30;

25. History of any type of GI Surgery.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Pennsylvania

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Garret FitzGerald, MD

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Locations

Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania

Philadelphia, Pennsylvania, United States

Countries

United States

References

Skarke C, Lahens NF, Rhoades SD, Campbell A, Bittinger K, Bailey A, Hoffmann C, Olson RS, Chen L, Yang G, Price TS, Moore JH, Bushman FD, Greene CS, Grant GR, Weljie AM, FitzGerald GA. A Pilot Characterization of the Human Chronobiome. Sci Rep. 2017 Dec 7;7(1):17141. doi: 10.1038/s41598-017-17362-6.

Reference Type: BACKGROUND

PMID: 29215023 (View on PubMed)

Other Identifiers

828944

Identifier Type: -

Identifier Source: org_study_id