Effect of Covid-19 on Hypertension

NCT ID: NCT05798208

Last Updated: 2023-04-04

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 5355 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-02-15
• Study Completion Date: 2023-02-20

Brief Summary

In this single center , retrospective study, 5355 covid patient were selected from 2020 to 2022, with recorded blood pressure before covid and recording after covid. Blood pressure before and after covid were compared, by pair T test.

Detailed Description

design and participants This single-center retrospective cohort study was conducted at an outpatient cardiology clinic in Shiraz, Iran, between February 15, 2020, and December 28, 2022. We evaluated patients with a confirmed diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by RNA reverse-transcriptase polymerase-chain-reaction assays from nasopharyngeal or oropharyngeal swab specimens according to World Health Organization guidelines (12). Two physicians (PA, MY) reviewed the patients' electronic medical records, including demographics, comorbidities, vital signs, treatments, and outcomes. Ambiguities were resolved by a third author (MM).

The current study included all COVID-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery. The following patients were excluded: those under 18, with hospital admission due to COVID-19, who received corticosteroid therapy, those with a history of systemic inflammatory disease, kidney or liver, immunocompromised patients, and those who switched their antihypertensive regimen during the study. Finally, 5,355 eligible patients were investigated . The primary outcome was to assess BP variation following infection (particularly a prolonged rise in BP) among non-hospitalized COVID-19 patients. The secondary outcome was to identify the predictor factors of BP variation.

The present study was approved by the Ethics Committee of Shiraz University of Medical Sciences under code IR.SUMS.MED.REC.1401.465 , and the need for informed consent was waived due to the study's retrospective nature and the absence of patient identifiers in the presented data.

Conditions

COVID-19; Hypertension

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

hypertensive

Covid patients with exacerbated hypertension or new hypertension post covid

blood pressure measurement

Intervention Type: DIAGNOSTIC_TEST

Taking blood pressure with automated arm sphygmomanometer and pressure higher than 140/90 was considered abnormal

non hypertensive

Covid patients with no change in blood pressure pre and post covid

blood pressure measurement

Intervention Type: DIAGNOSTIC_TEST

Taking blood pressure with automated arm sphygmomanometer and pressure higher than 140/90 was considered abnormal

Interventions

blood pressure measurement

Taking blood pressure with automated arm sphygmomanometer and pressure higher than 140/90 was considered abnormal

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• All COVID-19 patients who had at least one documented blood pressure measurement in the three months preceding infection and one documented measurement one to three months following recovery

Exclusion Criteria

• Age under 18
• Hospital admission due to COVID-19
• Corticosteroid therapy,
• History of systemic inflammatory disease
• kidney disease
• liver disease
• Immunocompromised patients

• Minimum Eligible Age: 39 Years
• Maximum Eligible Age: 71 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shiraz University of Medical Sciences

OTHER

Sponsor Role: lead

Responsible Party

Javad Kojuri

professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Cardiology Ward Shiraz University of Medical Sciences

Shiraz, Fars, Iran

Education Developmen Center

Shiraz, Fars, Iran

Professor kojuri cardiology clinic

Shiraz, Outside of the US, Iran

Countries

Iran

References

Azami P, Vafa RG, Heydarzadeh R, Sadeghi M, Amiri F, Azadian A, Khademolhosseini A, Yousefi M, Montaseri M, Hosseini N, Hosseini SA, Kojuri J. Evaluation of blood pressure variation in recovered COVID-19 patients at one-year follow-up: a retrospective cohort study. BMC Cardiovasc Disord. 2024 May 7;24(1):240. doi: 10.1186/s12872-024-03916-w.

Reference Type: DERIVED

PMID: 38714940 (View on PubMed)

Other Identifiers

IR.SUMS.MED.REC.1401

Identifier Type: -

Identifier Source: org_study_id