Circulating MrgD in Pulmonary Hypertension

NCT ID: NCT06365372

Last Updated: 2024-04-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-10

Study Completion Date

2024-06-01

Brief Summary

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The aim of the study is to observe the change of the circulating MrgD level in patients with pulmonary hypertension compared with subjects without pulmonary hypertension.

Detailed Description

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Conditions

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Pulmonary Hypertension

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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PAH

Western blot

Intervention Type DIAGNOSTIC_TEST

Samples were measured by Western blot using a solution for the separation of lymphocytes from peripheral blood.

Non-PAH

Western blot

Intervention Type DIAGNOSTIC_TEST

Samples were measured by Western blot using a solution for the separation of lymphocytes from peripheral blood.

Interventions

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Western blot

Samples were measured by Western blot using a solution for the separation of lymphocytes from peripheral blood.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1. Male or female aged ≥18 years
2. Right heart catheterisation to check the mean pulmonary artery pressure (mPAP) ≥25mmHg
3. The patient is willing and able to provide written informed consent.


1. Male or female aged ≥18 years
2. No evidence of pulmonary hypertension on echocardiography or mean pulmonary artery pressure (mPAP) \< 25 mmHg on right heart catheterization, and no evidence of clinically relevant heart disease
3. No evidence of clinically relevant pulmonary disease

Exclusion Criteria

1. Age less than 18 years old
2. Mean pulmonary artery pressure (mPAP) \<25mmHg
3. Unable to provide informed written consent for participation in the study
4. Renal insufficiency
5. Liver insufficiency
6. Malignant tumor
7. Active infection
8. Pregnancy


1. Age less than 18 years old
2. Mean pulmonary artery pressure (mPAP) ≥25mmHg
3. Unable to provide informed written consent for participation in the study
4. Symptoms of heart failure or clinically relevant lung disease
5. Renal insufficiency
6. Liver insufficiency
7. Malignant tumor
8. Active infection
9. Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Qilu Hospital of Shandong University

OTHER

Sponsor Role lead

Responsible Party

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Pan-Pan Hao

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Qilu Hospital of Shandong University

Jinan, Shandong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Panpan Hao, MD

Role: CONTACT

8618560086593

Facility Contacts

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Panpan Hao, MD, PHD

Role: primary

Other Identifiers

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MrgD and PAH

Identifier Type: -

Identifier Source: org_study_id

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