Structured Exercise Prescription Program in Obese Children

NCT ID: NCT03552367

Last Updated: 2018-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

140 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-01

Study Completion Date

2020-07-31

Brief Summary

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This controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity with a control group that will be enrolled in a multicomponent program without structured personalized exercise prescription. All children will be followed for a period of 6 months.

The parameters that will be evaluated between groups are physical fitness, anthropometry, metabolic (glucose oral tolerance curve, lipids, HOMA-IR, ISI-MATSUDA), early cardiovascular damage, inflammatory biomarkers, anxiety and depression scores, and allelic variants related to physical fitness.

Detailed Description

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This controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity (study group) with a control group that will be enrolled in a multicomponent program without structured personalized exercise prescription. All children will be followed for a period of 6 months.

The parameters that will be evaluated between groups are physical fitness (measured by VO2max, ECG at rest, biomechanics and dynamometry), anthropometric measurements (weight height, BMI, plicometry, bioimpedance, metabolic (glucose oral tolerance curve, lipids, HOMA-IR, ISI-MATSUDA), early cardiovascular damage (carotid intima-media thickness, atherogenic dyslipidemia), inflammatory biomarkers (leptin, adiponectin, IL-17, IL-10, INF-gamma, IL-6, IL-12, y TNF-alpha), anxiety and depression scores evaluated with Child Depression Inventory (CID) and -Trait Anxiety Inventory for Children (STAI-CH), and allelic variants related to physical fitness (ACTN, TRH2 y FTO).

Conditions

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Obesity Exercise Cardiovascular Risk Factor Liver Diseases Metabolic Syndrome Childhood Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized open clinical trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

This is an open-label trial

Study Groups

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Personalized structured exercise

This group will be enrolled in a multicomponent program for obese children (8-12 years old) that includes intervention workshops concerning nutrition, emotional factors, cognitive therapy and personalized structured exercise prescription that will be offered on-site and online and monitored through the use of heart rate monitoring devices. The type of exercise offered to patients in this arm is precisely designed for obese patients according to age and physical fitness parameters.

Intervention: Non-personalized non-structured exercise

Group Type EXPERIMENTAL

Personalized structured exercise program

Intervention Type OTHER

The type of exercise offered to patients in this arm is precisely designed for obese patients according to age and physical fitness parameters. Patients are monitored using a heart rate monitor to evaluate treatment adherence and compliance

Non-personalized non-structured exercise

This group will be enrolled in a multicomponent program for obese children (8-12 years old) that includes intervention workshops concerning nutrition, emotional factors, cognitive therapy and non-personalized non-structured exercise prescription Intervention: Non-personalized non-structured exercise

Group Type ACTIVE_COMPARATOR

Non personalized non-structured exercise program

Intervention Type OTHER

The type of exercise is non-structured and patients' heart rate is not monitored. Patients receive exercise recommendations without any personalization according to their fitness parameters

Interventions

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Personalized structured exercise program

The type of exercise offered to patients in this arm is precisely designed for obese patients according to age and physical fitness parameters. Patients are monitored using a heart rate monitor to evaluate treatment adherence and compliance

Intervention Type OTHER

Non personalized non-structured exercise program

The type of exercise is non-structured and patients' heart rate is not monitored. Patients receive exercise recommendations without any personalization according to their fitness parameters

Intervention Type OTHER

Other Intervention Names

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Structured exercise Non-structured exercise

Eligibility Criteria

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Exclusion Criteria

Presence of endocrine disease including type I and II diabetes mellitus Presence of arterial hypertension Presence of primary dyslipidemia Presence of infections at moment of enrollment Presence of systemic disease Presence of genetic disorder Medical treatment that may interfere with lipid or glucose metabolism Prolonged or acute immobilization Participated in a previous similar intervention
Minimum Eligible Age

8 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Council of Science and Technology, Mexico

OTHER

Sponsor Role collaborator

Fundacion Sertull

UNKNOWN

Sponsor Role collaborator

Universidad Nacional Autonoma de Mexico

OTHER

Sponsor Role collaborator

Hospital General de México Dr. Eduardo Liceaga

OTHER_GOV

Sponsor Role lead

Responsible Party

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Nayely Garibay Nieto

Head of the Child and Adolescent Obesity Clinic

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nayely Garibay Nieto, MD MSc

Role: PRINCIPAL_INVESTIGATOR

Director Child and Adolescent Obesity Clinic

Locations

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Hospital General de Mexico Eduardo Liceaga

Mexico City, Del. Cuauhtemoc, Mexico

Site Status RECRUITING

Countries

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Mexico

Central Contacts

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Nayely Garibay Nieto, MD MSc

Role: CONTACT

+5255 2789 2000

Facility Contacts

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Nayely Garibay iIeto, MD MSc

Role: primary

2789 2000

References

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Krebs NF, Himes JH, Jacobson D, Nicklas TA, Guilday P, Styne D. Assessment of child and adolescent overweight and obesity. Pediatrics. 2007 Dec;120 Suppl 4:S193-228. doi: 10.1542/peds.2007-2329D.

Reference Type BACKGROUND
PMID: 18055652 (View on PubMed)

American Dietetic Association (ADA). Position of the American Dietetic Association: individual-, family-, school-, and community-based interventions for pediatric overweight. J Am Diet Assoc. 2006 Jun;106(6):925-45. doi: 10.1016/j.jada.2006.03.001.

Reference Type BACKGROUND
PMID: 16812927 (View on PubMed)

Kelley GA, Kelley KS. Exercise and BMI z-score in overweight and obese children and adolescents: protocol for a systematic review and network meta-analysis of randomised trials. BMJ Open. 2016 Apr 15;6(4):e011258. doi: 10.1136/bmjopen-2016-011258.

Reference Type BACKGROUND
PMID: 27084289 (View on PubMed)

Kelley GA, Kelley KS, Pate RR. Exercise and BMI z-score in Overweight and Obese Children and Adolescents: A Systematic Review and Network Meta-Analysis of Randomized Trials. J Evid Based Med. 2017 May;10(2):108-128. doi: 10.1111/jebm.12228.

Reference Type BACKGROUND
PMID: 27792271 (View on PubMed)

Lison JF, Real-Montes JM, Torro I, Arguisuelas MD, Alvarez-Pitti J, Martinez-Gramage J, Aguilar F, Lurbe E. Exercise intervention in childhood obesity: a randomized controlled trial comparing hospital-versus home-based groups. Acad Pediatr. 2012 Jul-Aug;12(4):319-25. doi: 10.1016/j.acap.2012.03.003. Epub 2012 May 26.

Reference Type BACKGROUND
PMID: 22634075 (View on PubMed)

Other Identifiers

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DI/17/311/03/028

Identifier Type: -

Identifier Source: org_study_id

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