The Medical College of Georgia PLAY Project: Exercise Dose and Insulin Sensitivity in Obese Children

NCT ID: NCT00108901

Last Updated: 2014-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

222 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-06-30

Study Completion Date

2007-01-31

Brief Summary

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The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on risk for type 2 diabetes, fatness, fitness, blood cholesterol levels, and other cardiovascular risk factors in overweight elementary schoolchildren.

The hypothesis is that the more exercise a child does, the more benefit he or she will gain in reducing the risk of diabetes and other cardiovascular diseases.

An ancillary study examined effects on cognition and achievement.

Detailed Description

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The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on insulin response to the oral glucose tolerance test, body composition, fitness, lipid profile, inflammation and other metabolic syndrome components in overweight elementary schoolchildren.

Blinded psychological assessments of cognition and achievement were obtained.

Conditions

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Obesity Type 2 Diabetes Prevention Executive Function (Cognition)

Keywords

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prevention children diabetes overweight obesity metabolic syndrome exercise insulin resistance female male black, African-American white, Caucasian cognition executive function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Control

Children were not provided with an after-school exercise intervention. They were free to do their usual activities. Families were offered a monthly healthy lifestyle class.

Group Type NO_INTERVENTION

No interventions assigned to this group

Low Dose

This group was assigned to receive a 20 min/day aerobic exercise program offered 5 days/week after school. Families were offered a monthly healthy lifestyle class.

Group Type EXPERIMENTAL

Aerobic exercise program

Intervention Type BEHAVIORAL

Vigorous intermittent physical activity in group format conducted in research gymnasium after school by research staff. Heart rate monitors documented each child's average heart rate on a daily basis. Small incentives were offered for achieving goal of \>150 bpm average HR each day and attending at least 80% of sessions (4 days/week).

High dose

This group was assigned to receive a 40 min/day aerobic exercise program offered 5 days/week after school. Families were offered a monthly healthy lifestyle class.

Group Type EXPERIMENTAL

Aerobic exercise program

Intervention Type BEHAVIORAL

Vigorous intermittent physical activity in group format conducted in research gymnasium after school by research staff. Heart rate monitors documented each child's average heart rate on a daily basis. Small incentives were offered for achieving goal of \>150 bpm average HR each day and attending at least 80% of sessions (4 days/week).

Interventions

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Aerobic exercise program

Vigorous intermittent physical activity in group format conducted in research gymnasium after school by research staff. Heart rate monitors documented each child's average heart rate on a daily basis. Small incentives were offered for achieving goal of \>150 bpm average HR each day and attending at least 80% of sessions (4 days/week).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Overweight, sedentary children
* Black or white race
* Attending specific schools in Augusta, GA area from which this study is recruiting

Exclusion Criteria

* Unable to participate in testing or vigorous exercise program
* Diabetes
* Taking medication that would affect study results
* Sibling enrolled in project
Minimum Eligible Age

7 Years

Maximum Eligible Age

11 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role lead

Responsible Party

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Medical College of Georgia

Principal Investigators

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Catherine L Davis, PhD

Role: PRINCIPAL_INVESTIGATOR

Augusta University

Locations

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Georgia Prevention Institute, Medical College of Georgia

Augusta, Georgia, United States

Site Status

Countries

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United States

References

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Davis CL, Tkacz J, Gregoski M, Boyle CA, Lovrekovic G. Aerobic exercise and snoring in overweight children: a randomized controlled trial. Obesity (Silver Spring). 2006 Nov;14(11):1985-91. doi: 10.1038/oby.2006.232.

Reference Type RESULT
PMID: 17135615 (View on PubMed)

Davis CL, Tomporowski PD, Boyle CA, Waller JL, Miller PH, Naglieri JA, Gregoski M. Effects of aerobic exercise on overweight children's cognitive functioning: a randomized controlled trial. Res Q Exerc Sport. 2007 Dec;78(5):510-9. doi: 10.1080/02701367.2007.10599450.

Reference Type RESULT
PMID: 18274222 (View on PubMed)

Tomporowski PD, Davis CL, Miller PH, Naglieri JA. Exercise and Children's Intelligence, Cognition, and Academic Achievement. Educ Psychol Rev. 2008 Jun 1;20(2):111-131. doi: 10.1007/s10648-007-9057-0.

Reference Type RESULT
PMID: 19777141 (View on PubMed)

Davis CL, Pollock NK, Waller JL, Allison JD, Dennis BA, Bassali R, Melendez A, Boyle CA, Gower BA. Exercise dose and diabetes risk in overweight and obese children: a randomized controlled trial. JAMA. 2012 Sep 19;308(11):1103-12. doi: 10.1001/2012.jama.10762.

Reference Type DERIVED
PMID: 22990269 (View on PubMed)

Other Identifiers

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R01DK060692

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01DK070922

Identifier Type: NIH

Identifier Source: secondary_id

View Link

60692 (completed)

Identifier Type: -

Identifier Source: org_study_id