Regeneration of Immature Teeth. Case Series

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-28

Study Completion Date

2030-12-01

Brief Summary

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This clinical study aims to investigate the predictability of revascularization procedure of immature necrotic human permanent teeth with apical periodontitis. The quality of root development (thickness and length) will be assessed radiographically.

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Detailed Description

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All teeth will be disinfected using either triple antibiotic paste (a mixture of metronidazole, ciprofloxacin and amoxicillin mixed with sterile glycole) or non setting calcium hydroxide applied to the pulp space with a sterile lentulospiral and then closed temporarily with a sterile sponge and temporary restoration for 2-3 weeks to allow disinfection of the canals teeth will be reentered under rubber dam isolation and all intracanal medicaments will be washed out from the canal using 10 ml of 2.5% sodium hypochlorite and 20 ml of Ethylene diamine tetra acetic acid (EDTA). Then, a sterile endodontic file will be inserted past the canal terminus into the periapical tissues to induce bleeding to fill the canal space as much as possible and subsequently sealed with a double coronal seal using bioceramic repair material and composite filling. All the teeth will be monitored clinically and radiographically on a biannual basis.

Conditions

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Revascularization

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Revascularization for immature necrotic permanent teeth with apical periodontitis.

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Triple paste and induced bleeding

The triple paste is a mixture of metronidazole, ciprofloxacin and minocycline mixed with sterile glycol will be used and next visit intracanal bleeding will be induced

Group Type EXPERIMENTAL

Triple paste and induced bleeding

Intervention Type PROCEDURE

Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol

Intervention Type DRUG

triple paste of metronidazole, ciprofloxacin and minocycline mixed with sterile glycol

Interventions

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Triple paste and induced bleeding

Intervention Type PROCEDURE

Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol

triple paste of metronidazole, ciprofloxacin and minocycline mixed with sterile glycol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Teeth diagnosed with necrotic pulp with/without evidence of apical periodontitis.
2. An immature/open apex.
3. Tooth does not need post and core restoration.
4. Medically healthy patients with no known allergy to used materials.