Mental Stress & Diesel Exhaust on Cardiovascular Health
NCT ID: NCT03467997
Last Updated: 2018-11-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
22 participants
INTERVENTIONAL
2018-03-22
2020-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
TRIPLE
Study Groups
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Filtered Air
Subjects sit in a room for two hours breathing in filtered air which resembles levels of air pollution found in the ambient environment
No interventions assigned to this group
Diesel Exhaust
Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed.
Diesel exhaust
Diesel exhaust is an air pollutant found in the environment and produced by cars, trucks and other transportation modes (e.g. trains, planes).
TSST/Stress only
Subjects undergo a mental stress test, known as the Trier Social Stress Test (TSST), which involves a public speaking and math task.
Trier social stress test
Subjects are asked to give a 5 minute speech on a topic selected by the investigator. Then they are asked to subtract 7 from 758.
Diesel Exhaust and stress
Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed and are subject to a mental stress test (TSST) which involves a public speaking and math task.
Trier social stress test
Subjects are asked to give a 5 minute speech on a topic selected by the investigator. Then they are asked to subtract 7 from 758.
Diesel exhaust
Diesel exhaust is an air pollutant found in the environment and produced by cars, trucks and other transportation modes (e.g. trains, planes).
Interventions
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Trier social stress test
Subjects are asked to give a 5 minute speech on a topic selected by the investigator. Then they are asked to subtract 7 from 758.
Diesel exhaust
Diesel exhaust is an air pollutant found in the environment and produced by cars, trucks and other transportation modes (e.g. trains, planes).
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. History of high blood pressure: We objectively measure BP during in-person screening and exclude those with blood pressure (\>130/85 mmHg).
3. Asthmatic: Spirometry is done at screening to rule out asthma.
4. Diabetic: We obtain fasting blood sugar to rule out diabetes at screening (\>125 mg/dL)
5. Cholesterol: We obtain fasting blood lipid levels to rule out hypercholesterolemia at screening (\>200 mg/dL).
6. History of PTSD: Subjects will be asked about prior PTSD diagnosis during the phone and in person screen.
7. Any other chronic condition requiring ongoing care based on medication use.
8. A body mass index (weight in kilograms divided by height in meters squared) greater than 26 and less than 18.5
9. A female of childbearing age with a positive pregnancy test
10. A female of childbearing age who is unwilling to use effective contraception during the study
22 Years
49 Years
ALL
Yes
Sponsors
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National Institute of Environmental Health Sciences (NIEHS)
NIH
University of Washington
OTHER
Responsible Party
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Anjum Hajat
Assistant Professor
Principal Investigators
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Anjum Hajat, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Washington
Locations
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University of Washington Diesel Exhaust Facility
Seattle, Washington, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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STUDY00002051
Identifier Type: -
Identifier Source: org_study_id
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