Effect of Galactose Ingestion on Postprandial Lipemia

NCT ID: NCT03439878

Last Updated: 2018-05-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-01

Study Completion Date

2018-05-01

Brief Summary

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This study aims to assess the postprandial triglyceride response to the ingestion of a high-fat meal with co-ingestion of either galactose, or glucose.

Detailed Description

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Conditions

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Cardiovascular Risk Factor Lipemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Randomized, blinded crossover design.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Outcome Assessors
Participants and the researchers performing biochemical analyses will be blinded to the intervention.

Study Groups

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Galactose

Ingestion of 0.75 g/kg body mass of d-galactose monohydrate co-ingested with cream to provide 1 g/kg body mass of fat.

Group Type EXPERIMENTAL

Galactose

Intervention Type DIETARY_SUPPLEMENT

Co-ingestion of d-galactose with a high-fat meal

Glucose

Ingestion of 0.75 g/kg body mass of dextrose monohydrate co-ingested with cream to provide 1 g/kg body mass of fat.

Group Type ACTIVE_COMPARATOR

Glucose

Intervention Type DIETARY_SUPPLEMENT

Co-ingestion of d-glucose with a high-fat meal

Interventions

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Galactose

Co-ingestion of d-galactose with a high-fat meal

Intervention Type DIETARY_SUPPLEMENT

Glucose

Co-ingestion of d-glucose with a high-fat meal

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male
* 18 to 35 years old
* Body mass index \<30 kg/m2

Exclusion Criteria

* Female
* Body mass index \>29.9 kg/m2
* Any history of metabolic disease
* Allergies or intolerances to milk and/or cream
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Bath

OTHER

Sponsor Role lead

Responsible Party

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Javier Gonzalez

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department for Health, University of Bath

Bath, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Watkins J, Simpson A, Betts JA, Thompson D, Holliday A, Deighton K, Gonzalez JT. Galactose Ingested with a High-Fat Beverage Increases Postprandial Lipemia Compared with Glucose but Not Fructose Ingestion in Healthy Men. J Nutr. 2020 Jul 1;150(7):1765-1772. doi: 10.1093/jn/nxaa105.

Reference Type DERIVED
PMID: 32297937 (View on PubMed)

Other Identifiers

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MSES 16/17-011

Identifier Type: -

Identifier Source: org_study_id

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