Effects of Intranasal Oxytocin on Functional Brain Network in Resting-state and Tasks

NCT ID: NCT03428906

Last Updated: 2018-02-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-05-24
• Study Completion Date: 2017-09-12

Brief Summary

To investigate whether and how intranasal oxytocin of 8IU treatment will alter the topology of functional brain network in resting-state and multiple tasks in healthy males.

Detailed Description

In a randomized, double-blind, cross-over, placebo controlled design, healthy male volunteers receive intranasal oxytocin or placebo prior to functional magnetic resonance imaging.Subjects will then go through a decision making task, a emotion judgement task and an eight-minute resting-state scan in MRI scanner to investigate whether and how intranasal oxytocin alter the topology of functional brain network in resting-state and multiple tasks in healthy males. State anxiety and mood are measured before and after experiment as covariates to be controlled.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Oxytocin

Oxytocin (OXT), a neuropeptide produced in the hypothalamus, is a key modulator of complex socioaffective responses including affiliation, social approach and attachment, stress and anxiety. Subjects receiving an intranasal spray of OXT (8 IU or 13.44 mg; Syntocinon-spray; Novartis, Switzerland) .

Group Type: EXPERIMENTAL

Oxytocin

Intervention Type: DRUG

intranasally administrated

Placebo

Placebo contains all ingredients except for the peptide in three puffs of 1.33 IU per 2.24mg nostril.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

intranasally administrated

Interventions

Oxytocin

intranasally administrated

Intervention Type: DRUG

Placebo

intranasally administrated

Intervention Type: DRUG

Other Intervention Names

Saline

Eligibility Criteria

Inclusion Criteria

• healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• with MRI Contraindications

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Beijing Normal University

OTHER

Sponsor Role: lead

Responsible Party

ma, yina

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yina Ma, PhD

Role: PRINCIPAL_INVESTIGATOR

School of Brain and Cognitive Sciences, Beijing Nornal University

Locations

School of Brain and Cognitive Sciences, Beijing Nornal University

Beijing, Beijing Municipality, China

Countries

China

Other Identifiers

IN-OT functional network

Identifier Type: -

Identifier Source: org_study_id