Ocytocine and Cerebral Activation in Relation With Attachement
NCT ID: NCT02847143
Last Updated: 2024-10-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
100 participants
INTERVENTIONAL
2015-04-09
2018-04-27
Brief Summary
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Detailed Description
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They will have 2 fMRI sessions, during which emotional images will be presented.
One session will be preceded by a nasal administration of oxytocin and the other session will be preceded by a placebo nasal administration. The order of both administrations will be randomized.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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secure
healthy adult male with secure attachement
nasal oxytocin or placebo
nasal administration of oxytocin or palcebo 45 min befor fMRI session
fMRI
FMRI during emotional image visualization
Attachement scale interview (ASI)
this scale is used to determine the attachement style of each participant
psychometric scales
self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20)
avoidant
healthy adult male with avoidant attachement
nasal oxytocin or placebo
nasal administration of oxytocin or palcebo 45 min befor fMRI session
fMRI
FMRI during emotional image visualization
Attachement scale interview (ASI)
this scale is used to determine the attachement style of each participant
psychometric scales
self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20)
enmeshed/fearfull
healthy adult male with enmeshed/fearfull attachement
nasal oxytocin or placebo
nasal administration of oxytocin or palcebo 45 min befor fMRI session
fMRI
FMRI during emotional image visualization
Attachement scale interview (ASI)
this scale is used to determine the attachement style of each participant
psychometric scales
self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20)
dual style
healthy adult male with dual attachement style
nasal oxytocin or placebo
nasal administration of oxytocin or palcebo 45 min befor fMRI session
fMRI
FMRI during emotional image visualization
Attachement scale interview (ASI)
this scale is used to determine the attachement style of each participant
psychometric scales
self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20)
Interventions
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nasal oxytocin or placebo
nasal administration of oxytocin or palcebo 45 min befor fMRI session
fMRI
FMRI during emotional image visualization
Attachement scale interview (ASI)
this scale is used to determine the attachement style of each participant
psychometric scales
self adminstrated questionnaires which asses the level of anxiety (Spielberger State-trait anxiety interview-STAI), depression (Beck depression inventory-BDI) and alexithymia (Toronta Alexuthymia scale-TAS 20)
Eligibility Criteria
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Inclusion Criteria
* having signed the informed consent
Exclusion Criteria
* hypertensive treatment
* treatment wich increases QT
* current hospitalisation
* fMRI contraindication
* legal protection
18 Years
30 Years
MALE
Yes
Sponsors
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Centre Hospitalier Universitaire de Besancon
OTHER
Responsible Party
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Principal Investigators
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Lauriane VULLIEZ-COADY, MD
Role: PRINCIPAL_INVESTIGATOR
Centre Hospitalier Universitaire de Besancon
Locations
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CHU Besancon
Besançon, Doubs, France
Countries
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References
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Comte A, Szymanska M, Monnin J, Moulin T, Nezelof S, Magnin E, Jardri R, Vulliez-Coady L. Neural correlates of distress and comfort in individuals with avoidant, anxious and secure attachment style: an fMRI study. Attach Hum Dev. 2024 Oct;26(5):423-445. doi: 10.1080/14616734.2024.2384393. Epub 2024 Aug 2.
Other Identifiers
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P/2014/237
Identifier Type: -
Identifier Source: org_study_id
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