Techniques for Perioperative Analgesia for Live Liver Donors; A Pilot Study
NCT ID: NCT03393988
Last Updated: 2018-01-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
20 participants
INTERVENTIONAL
2017-12-07
2019-02-28
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Group F
Fentanyl infusion (0.5 µg/kg/hr)
Fentanyl infusion
After induction of general anesthesia; Fentanyl infusion (0.5 µg/kg/hr) will be started (which will be afterwards adjusted intraoperatively according to the hemodynamics and Bispectral Index (BIS) reading).
Group (TAP-Dex)
Ultrasound guided TAP block and Dexmedetomidine
* Ultrasound guided subcostal oblique TAP block with 0.25 % bupivacaine
* Dexmedetomidine infusion(200 µg in 2 ml diluted in 48 ml of saline)
* Fentanyl infusion (0.5 µg/kg/hr).
Fentanyl infusion
After induction of general anesthesia; Fentanyl infusion (0.5 µg/kg/hr) will be started (which will be afterwards adjusted intraoperatively according to the hemodynamics and Bispectral Index (BIS) reading).
Ultrasound guided TAP block
After induction of general anesthesia; Patients will receive ultrasound guided subcostal oblique TAP block with 0.25 % bupivacaine 40 ml on each side resulting in a total volume of 80 ml, subcostal TAP block was given twice, at the beginning and at the end of the surgery.
Dexmedetomidine
Dexmedetomidine (200 µg in 2 ml diluted in 48 ml of saline) will be started in a dose of 1 μg/kg over 10 min then maintenance dose as continuous infusion between 0.2 and 0.8 μg/ kg/h through infusion pump (which will be adjusted according to the hemodynamics and BIS reading)
Interventions
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Fentanyl infusion
After induction of general anesthesia; Fentanyl infusion (0.5 µg/kg/hr) will be started (which will be afterwards adjusted intraoperatively according to the hemodynamics and Bispectral Index (BIS) reading).
Ultrasound guided TAP block
After induction of general anesthesia; Patients will receive ultrasound guided subcostal oblique TAP block with 0.25 % bupivacaine 40 ml on each side resulting in a total volume of 80 ml, subcostal TAP block was given twice, at the beginning and at the end of the surgery.
Dexmedetomidine
Dexmedetomidine (200 µg in 2 ml diluted in 48 ml of saline) will be started in a dose of 1 μg/kg over 10 min then maintenance dose as continuous infusion between 0.2 and 0.8 μg/ kg/h through infusion pump (which will be adjusted according to the hemodynamics and BIS reading)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Scheduled as live liver donors
* J-shaped incision in the supraumblical region
Exclusion Criteria
* Hypertensive patients,
* Morbidly obese patients,
* Pregnant and nursing women,
* Patients with known allergic reaction to any of the study medications,
* Patients on recent use of sedatives or analgesics,
* Patients with significant laboratory abnormalities
20 Years
50 Years
ALL
No
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Rasha Samir Abd-ElWahab Bondok
Professor
Locations
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Hospitals of Faculty of Medicine , Ain Shams University
Cairo, , Egypt
Countries
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Other Identifiers
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FMASU R45/2017
Identifier Type: -
Identifier Source: org_study_id
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