Perioperative Epidural Anesthesia and Analgesia on Gut Microbiota
NCT ID: NCT04079673
Last Updated: 2021-10-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2019-10-19
2022-07-31
Brief Summary
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The body microorganisms that reside in the human intestinal tract, referred to as the gut microbiota, are essential to human metabolism and immunity. The physiological functions of microbiota include defense against pathogens, providing nutrients such as vitamin B12 folate and vitamin K, and modulating gut integrity and permeability. Despite relatively stable microbiota during life, different illnesses, surgeries, medications dietary factors, and lifestyle changes could contribute to the imbalance of ecosystems resulting many gastrointestinal and extra-gastrointestinal disorders. Many researches have established a relationship between the gut microbiome and patients with liver disease such as liver cirrhosis, alcoholic liver disease and obesity related liver diseases etc. These liver disorders are associated with bacterial overgrowth, dysbiosis, and increased intestinal permeability. However, the relationship between hepatectomy and microbiota has not been fully investigated, especially in healthy liver donors.
Many routine perioperative management can impact the state of the microbiome and therefore can impact clinical outcomes, like bowel preparation and antibiotics. Potential factors affecting the gut microbiota also include perioperative manipulation, stress released hormones, and opioids. Maintenance of proper anesthetic depth is beneficial to attenuate surgical stress. However, general anesthesia including volatile anesthetics and opioids, is associated with altered gut microbiota. Therefore, regional anesthesia and analgesia which effectively attenuating surgical stress while efficiently reducing general anesthetics consumption, seem to provide promising advantages. Epidural analgesia has been proved to improve gastrointestinal function in major abdominal and thoracic surgery. However, the effect of perioperative epidural anesthesia and analgesia on microbiota is not clear.
Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Patient controlled epidural analgesia
Use of patient controlled epidural analgesia (PCEA) for postoperative pain control
Patient controlled epidural analgesia
Patient controlled epidural analgesia with marcaine 0.66mg/ml +fentanyl 1.75mcg/ml for postoperative pain control
Intravenous patient controlled analgesia
Use of intravenous patient controlled analgesia(IVPCA) for postoperative pain control
Intravenous patient controlled analgesia
Intravenous patient controlled analgesia with morphine 1mg/ml for postoperative pain control
Interventions
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Patient controlled epidural analgesia
Patient controlled epidural analgesia with marcaine 0.66mg/ml +fentanyl 1.75mcg/ml for postoperative pain control
Intravenous patient controlled analgesia
Intravenous patient controlled analgesia with morphine 1mg/ml for postoperative pain control
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
2. Previous gastrointestinal surgery.
20 Years
55 Years
ALL
No
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Principal Investigators
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Kuang-Cheng Chan, M.D.,PhD
Role: PRINCIPAL_INVESTIGATOR
Department of Anesthesiology, Natioanal Taiwan University Hospital
Locations
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Department of Anesthesiology, National Taiwan University Hospital
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Kuang-Cheng Chan, M.D.,PhD
Role: primary
Other Identifiers
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201812090RINC
Identifier Type: -
Identifier Source: org_study_id