Investigating Neural Processing of Social Stimuli

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-01

Study Completion Date

2019-04-01

Brief Summary

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The primary goal of the present study is to test whether neural activity in brain regions associated with processing threat and social stimuli may underlie paranoid thinking.

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Detailed Description

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Paranoia is a prominent symptom of psychosis that occurs in several other diagnoses, as well as the general population, and that is associated with significant distress and impairment. Previous research suggests that increased baseline activity of the amygdala and related neural circuits may serve as a mechanism for paranoid ideation. This exploratory study will use a paranoia induction procedure in healthy individuals who vary in pre-existing levels of paranoid ideation to test whether increases in self-reported paranoia are accompanied by increases in resting cerebral blood flow (CBF), decreased stimulus-driven neural activity in social processing networks, and increased behavioral perceptions of untrustworthiness.

Participants will be randomly assigned to participate in a paranoia induction procedure or a control condition and will then complete neuroimaging and behavioral assessments.

Conditions

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Healthy Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Paranoia Induction

Behavioral procedure involving social exclusion and negative feedback to induce paranoia

Group Type EXPERIMENTAL

Paranoia Induction

Intervention Type BEHAVIORAL

Behavioral procedure involving social exclusion and negative feedback to induce paranoia

Control Condition

No manipulation of paranoid ideation

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Paranoia Induction

Behavioral procedure involving social exclusion and negative feedback to induce paranoia

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* between the ages of 18 and 55

Exclusion Criteria

* current psychiatric diagnosis
* current use of psychotropic medications
* history of head trauma with loss of consciousness for more than 15 minutes
* presence of neurological or neurodegenerative disorder
* sensory impairments that preclude assessment
* presence of intellectual disability
* contraindications for MRI (e.g., metallic implants or pregnancy)

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes