Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients

NCT ID: NCT03355625

Last Updated: 2022-05-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

33 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-01

Study Completion Date

2019-11-30

Brief Summary

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The primary aim is to describe platelet function in adult patients treated with extracorporeal membrane oxygenation (ECMO). A clarification of the platelet function in these critically ill patients contributes to an understanding of the mechanisms underlying their coagulopathy.

The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).

Detailed Description

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The knowledge of platelet function during extracorporeal membrane oxygenation (ECMO) remains sparse. In the present study, the aim is to investigate platelet function in adult patients treated with ECMO using flow cytometry. The investigators hypothesize that platelet function increases from day 1 to day 3 in patients treated with ECMO. The secondary aim is to investigate the association between platelet function and the incidence of bleeding episodes and thrombosis during ECMO treatment.

The present study is a substudy to the study entitled; "Coagulopathy During Extracorporeal Membrane Oxygenation" (pending Clinical Trial ID number).

Conditions

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Extracorporeal Membrane Oxygenation Platelet Activation Platelet Aggregation Platelet Function Tests Blood Platelets Intensive Care Units

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Treatment with veno-venous or veno-arterial ECMO
* Age ≥18 years

Exclusion Criteria

* ECMO treatment initiated post-operatively
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Aarhus

OTHER

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Camilla Mains Balle, Research fellow

Role: PRINCIPAL_INVESTIGATOR

Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital

Anne-Mette Hvas, Professor, MD, PhD

Role: STUDY_CHAIR

Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital

Anni Nørgaard Jeppesen, MD, PhD

Role: STUDY_CHAIR

Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital

Steffen Christensen, MD, PhD

Role: STUDY_CHAIR

Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital

Locations

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Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital

Aarhus, , Denmark

Site Status

Department of Anaesthesiology and Intensive Care Unit East, Aarhus University Hospital

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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ECMO-Camilla

Identifier Type: -

Identifier Source: org_study_id

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