Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

93 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-18

Study Completion Date

2021-06-23

Brief Summary

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There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation. It is unknown whether the choice of anesthesia is impacted on the outcomes for these patients or not. The investigators will perform a randomized controlled pilot clinical trial of general anesthesia versus local anesthesia/conscious sedation to explore and find out a potential fact whether anesthetic type alters perioperative neurological function in patients with acute ischemic stroke in posterior cerebral circulation.

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Detailed Description

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Conditions

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Posterior Circulation Brain Infarction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Local anesthesia/conscious sedation

Patients will be injected by propofol (adjusted by bispectral index scale ≥70 ) and /or remifentanil（0.01-0.06μg/kg/min）. Patients will maintain spontaneous breathing.

Group Type OTHER

Local anesthesia/concious sedation

Intervention Type PROCEDURE

Patients will be injected with propofol and remifentanil.

Spontaneous breath

Intervention Type PROCEDURE

Patients will be kept spontaneous breath.

General anesthesia

Patients will be induced with remifentanil (0.2-0.8 μg/kg), propofol (1-2mg/kg) and rocuronium (0.6 mg/kg). Anesthesia will then be maintained keep the BIS between 40 and 60 with propofol and remifentanil. After tracheal intubation, patients will be kept with controlled ventilation.

Group Type OTHER

General anesthesia

Intervention Type PROCEDURE

Patients will be injected with propofol, remifentanil and muscular relaxant with controlled ventilation.

Controlled ventilation

Intervention Type PROCEDURE

Patient will be kept with controlled ventilation.

Interventions

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General anesthesia

Patients will be injected with propofol, remifentanil and muscular relaxant with controlled ventilation.

Intervention Type PROCEDURE

Local anesthesia/concious sedation

Patients will be injected with propofol and remifentanil.

Intervention Type PROCEDURE

Spontaneous breath

Patients will be kept spontaneous breath.

Intervention Type PROCEDURE

Controlled ventilation

Patient will be kept with controlled ventilation.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with acute ischemic stroke in posterior cerebral circulation scheduled to receive emergency endovascular treatment; Age \> 18; The onset time is within 24 hours; Modified rankin score ≤2 before onset.

Exclusion Criteria

* Radiological ambiguity concerning infarction and vessel occlusion; Additional intracerebral hemorrhage; Anterior circulation infraction; Coma on admission (Glasgow coma score less than 8); NIHSS less than 6 or more than 30; Severe agitation or seizures on admission; Obvious loss of airway protective reflexes and/or vomiting on admission; Being intubated before treatment on admission; Known allergy to anesthetic or analgesic;

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No