Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts

NCT ID: NCT03297736

Last Updated: 2020-09-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-03-01

Study Completion Date

2023-03-31

Brief Summary

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Prospectively analyze the use of 3D subtraction CAD/CAM in the operating room environment. Study participants, requiring middle ear surgery and ossicular reconstruction, will be implanted with one of two middle ear implants. The rationale is to complete a pilot study of the technology with a small number of designs. Each implant will be commonly used, in the public domain, and recreated by the CAD/CAM software.

Detailed Description

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Conventional middle ear prosthetic prosthetics, including total ossicular replacement prostheses (TORPs) and partial ossicular replacement prostheses (PORPs) are expensive, require large inventories for otologic surgery services, and carry the risk of extrusion or rejection. Autologous bone and cartilage can be used for many of these applications, but it requires expensive operating room time for carving to the appropriate shape and size.

The above considerations led to the concept of subtractive 3D CAD/CAM (computer assisted design/computer assisted manufacture) to produce accurate bone and cartilage autografts on demand in the operating room. Such a technology is hypothesized to save money by reducing operating room time, and reducing the need for expensive inventories of various shapes, sizes, and types of prosthetic devices. Since autologous materials are hypothesized to be less likely to extrude or cause other problems such as infection, this could also reduce costs.

Conditions

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Middle Ear Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DEVICE_FEASIBILITY

Blinding Strategy

SINGLE

Participants

Study Groups

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Control

Subjects receive the control device.

Group Type ACTIVE_COMPARATOR

Control device

Intervention Type DEVICE

Surgical ossicular reconstruction with the standard available middle ear prosthesis.

Investigational device

Subject receives the 3D CAD/CAM autograft prosthesis implant.

Group Type EXPERIMENTAL

3D CAD/CAM autograft prosthesis

Intervention Type DEVICE

Surgical ossicular reconstruction with the experimental autograft prosthesis created using 3D subtraction CAD/CAM.

Interventions

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3D CAD/CAM autograft prosthesis

Surgical ossicular reconstruction with the experimental autograft prosthesis created using 3D subtraction CAD/CAM.

Intervention Type DEVICE

Control device

Surgical ossicular reconstruction with the standard available middle ear prosthesis.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* at least 18 years of age with middle ear disease requiring surgical ossicular reconstruction

Exclusion Criteria

* congenital anomalies
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nitinetics LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Glenn Knox, M.D., J.D.

Role: PRINCIPAL_INVESTIGATOR

Nitinetics LLC

Locations

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University of Florida-Jacksonville

Jacksonville, Florida, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Glenn Knox, M.D., J.D.

Role: CONTACT

(904) 244-3498

Alisa Knox

Role: CONTACT

Facility Contacts

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Glenn Knox, M.D., J.D.

Role: primary

904-244-3498

Other Identifiers

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3D CAD/CAM

Identifier Type: -

Identifier Source: org_study_id

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