Effect of Caffeine on Ocular Circulation in High Myopes
NCT ID: NCT03294967
Last Updated: 2020-07-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2017-09-01
2019-12-31
Brief Summary
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Detailed Description
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With an advancement of technology such as optical coherence tomography (OCT), choroidal thickness can be measured, which indicates blood supply to outer retina. In addition, superficial retinal vasculature can be measured using optical coherence tomography angiography (OCTA).
Previous studies found that subfoveal choroidal thickness declined with increase in myopia. A negative association between subfoveal choroidal thickness and axial length was also found. A recent study found a negative association between retinal vessel density with axial length in Chinese myopes using OCTA. Therefore, caffeine consumption may further make high myopes prone to ocular diseases development due to poor ocular circulation.
The current study will use OCTA to measure the superficial retinal vasculature and OCT to measure choroidal thickness and choroidal volume of high myopes after consumption of caffeine capsule.
Statistical analysis
Normality of data will be assessed. The effect of caffeine on choroidal thickness, choroidal volume, vessel density, and perfusion density of superficial retinal layers will be analysed using repeated-measures ANOVA (co-variates) to compare baseline data and that after caffeine consumption at various time points. If significant difference is obtained, post hoc tests will be conducted to compare results from various time points with the baseline data. Difference between different age groups will be compared using unpaired t-test or Mann Whitney test, as appropriate.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
DIAGNOSTIC
SINGLE
Study Groups
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Caffeine
To determine the effect of caffeine on ocular circulation in high myopes by consuming 200 mg caffeine capsule
Caffeine
As in group descriptions
Vitamin E
To determine the effect of caffeine on ocular circulation in high myopes by consuming and 200 International Unit vitamin E control capsule, as control
Vitamin E
As in group descriptions
Interventions
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Caffeine
As in group descriptions
Vitamin E
As in group descriptions
Eligibility Criteria
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Inclusion Criteria
* Best corrected visual acuity of at least 6/6
* Non-smoker
Exclusion Criteria
20 Years
49 Years
ALL
Yes
Sponsors
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The Hong Kong Polytechnic University
OTHER
Responsible Party
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Dr Andrew KC Lam
Associate Professor
Principal Investigators
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Kwok Cheung Andrew Lam, PhD
Role: PRINCIPAL_INVESTIGATOR
The Hong Kong Polytechinc University
Locations
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School of optometry
Hong Kong, , Hong Kong
Countries
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Other Identifiers
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HSEARS20170613002
Identifier Type: -
Identifier Source: org_study_id
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