Expression of G-protein Coupled Receptor 120 Receptor in Adipose Tissue of German Diabetes Center Cohort Subjects
NCT ID: NCT03285750
Last Updated: 2023-06-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
50 participants
OBSERVATIONAL
2013-08-31
2017-09-30
Brief Summary
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Moreover, in obese subjects, a single nucleotide polymorphism (R270H) has been identified that inhibits GPR120 signaling activity.
The investigators now want to investigate if GPR120 expression in adipose tissue may be altered in patients with T2D compared to non-diabetic subjects and might contribute to diabetes-associated metabolic changes. Additionally, the investigators want to assess the frequency of the R270H mutant in T2D.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Diabetic group
Patients with recently diagnosed type 2 diabetes
No interventions assigned to this group
Controls
Age- and BMI-matched normoglycemic subjects
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* BMI \< 27,5 or \> 30 kg/m2
* Age 20 - 69 years
Exclusion Criteria
* anemia
* medication altering fatty acid metabolism
20 Years
69 Years
ALL
Yes
Sponsors
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German Diabetes Center
OTHER
Responsible Party
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Principal Investigators
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Michael Roden, Prof., MD
Role: PRINCIPAL_INVESTIGATOR
German Diabetes Center
Locations
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German Diabetes Center
Düsseldorf, North Rhine-Westphalia, Germany
Countries
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Other Identifiers
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GPR120 study
Identifier Type: -
Identifier Source: org_study_id
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