Quantitative Non-Invasive Brain Imaging Using QUTE-CE MRI

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-08

Study Completion Date

2020-07-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This trial will evaluate a non-invasive brain imaging technique QUTE-CE MRI and validate the method with first-in-human studies.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Neuraceq™ PET for Detection of Brain Changes in Young Athletes Post-concussion

NCT05270083

Concussion, Brain

COMPLETED NA

A Study of the Effects of LY3372689 on the Brain in Healthy Participants

NCT03944031

Healthy

COMPLETED PHASE1

Non-Heme Iron Load Quantification in the Brain - MRI of Patients With Stroke

NCT01829386

Stroke

COMPLETED

Safety and Efficacy of Gadobutrol 1.0 Molar (Gadavist) in Patients for Central Nervous System (CNS) Imaging

NCT00709852

Diagnostic Imaging Central Nervous System Diseases

COMPLETED PHASE3

Technical Development of Multi-Parametric Renocerebral MRI

NCT02831335

Aging

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This trial will evaluate a non-invasive brain imaging technique QUTE-CE MRI using Ferumoxytol as a contrast agent, and validate the method with first-in-human studies. Subjects who are already scheduled to receive ferumoxytol infusion will undergo MRI scans after the infusion. The ferumoxytol infusion itself is not a part of the study. The project will provide brain angiograms and establish a human cerebrovascular atlas that will enable future quantitative diagnosis of cerebrovascular abnormalities by revealing abnormal regions of the brain that characterize disease, a tool which doesn't currently exist, and which could lead to many exciting discoveries and clinical applications in neurology.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cerebrovascular Disorders

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Quantitative Magnetic Resonance Imaging

Radiological diagnosis

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Between the ages of 18 to 80;
* Able to understand written consent document and HIPAA authorization prior to initiation of study related procedures.

Exclusion Criteria

* Known allergy to ferumoxytol or any intravenous iron preparation;
* Iron saturation above the upper limit of normal;
* Individuals with a contraindication to MRI, such as the presence of metallic prostheses or implanted metal device (e.g., infusion pump, defibrillator);
* Individuals with known clinical conditions that may lead to iron overload including hemochromatosis, cirrhosis, or sickle cell disease;
* Individuals with any serious medical condition that the investigator believes may place them at increased risk for an adverse event.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No