Acute Concussion Management in Emergency Medicine with 7T MRI: a Feasibility Study
NCT ID: NCT06830616
Last Updated: 2025-02-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
20 participants
OBSERVATIONAL
2025-02-28
2025-11-30
Brief Summary
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To do this, the investigators will study 7T MRI brain imaging in patients aged 18-40 who present to the Emergency Department within 96 hours of a head injury. Patients will be eligible if they have had a normal CT brain as part of their usual care.
The investigators will compare brain imaging from patients who have completely recovered from an episode of concussion to patients who still have significant symptoms at approximately 28 days after a head injury.
The study attempts to answer the following questions:
1. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes to the blood vessels at approximately 28 days after their injury in comparison to patients who have recovered fully?
2. Do patients with ongoing symptoms after concussion show greater 7T MRI brain imaging evidence of changes in brain signaling pathways at approximately 28 days after their injury, in comparison to patients who have recovered fully?
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Detailed Description
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Lifetime incidence of concussion will be assessed at 7T MRI using the a modified version of the Brain Injury Screening Questionnaire (BISQ).
Information will also be collected regarding painkiller use, anticoagulation, return to work, and any related further unscheduled care admissions or CT head imaging.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Patients who have completely recovered from concussion
Recovery from concussion will be assessed at 25 +/- 3 days using a validated symptom score, the Post Concussion Symptom Scale (PCSS). This group will have a PCSS = 0.
7T MRI brain
A very detailed MRI scan of the brain using a 7T MRI scanner.
Patients who have ongoing symptoms from concussion
Recovery from concussion will be assessed at 25 +/- 3 days using a validated symptom score, the Post Concussion Symptom Scale (PCSS). This group will have a PCSS \> 10.
7T MRI brain
A very detailed MRI scan of the brain using a 7T MRI scanner.
Interventions
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7T MRI brain
A very detailed MRI scan of the brain using a 7T MRI scanner.
Eligibility Criteria
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Inclusion Criteria
2. Initial review within 96h of injury
3. No acute findings on CT head
4. Aged 18-40 years
Exclusion Criteria
2. Patient unable to speak and understand English
3. Patients where alternative diagnosis cannot be excluded
4. Polytrauma
5. Contra-indication to MRI
6. BMI \>40 or unable to comfortably lie on MRI scanner
7. Pregnant
8. Major confounding neurological disease e.g Multiple sclerosis, Stroke, Parkinson's Disease.
9. Patient participation in other research studies concurrently
18 Years
40 Years
ALL
No
Sponsors
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NHS Greater Glasgow and Clyde
OTHER
Responsible Party
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Central Contacts
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Other Identifiers
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INGN24HS153
Identifier Type: -
Identifier Source: org_study_id
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