Neurophysiological Examination in Patients With Brain Death

NCT ID: NCT03262896

Last Updated: 2019-10-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 10 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-15
• Study Completion Date: 2019-09-15

Brief Summary

This study examines muscle movements of elecromyography in adults with brain death. Half of the participants will have brain death, the other half will be healthy volunteers.

Detailed Description

In some of the patients who have brain death diagnosis, some movements may be seen. Because of these movements, the doctors sometimes avoid to make brain death diagnosis. So making brain death diagnosis may delay. And in these patients, even if the brain death diagnosis made the family members refuse to donate the organs of the patients because they think their patients may survive when they see muscle movements with touch. These patients with brain death are lost in a short time, so some of the patients can not be used as donors. In this study, the investigators aim to raise awareness the movements in brain death patients can be seen, to study the movements neurophysiologically by EMG, whether EMG can be used as auxiliary method or not in brain death diagnosis and to raise organ donation numbers from cadavers. Investigators will examine the motor response and F response in the facial nerve, median nerve, and tibialis posterior nerve with electromyography neurophysiologically.

Conditions

Brain Death

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Patients with brain death

Ten patients with definite etiology, who were diagnosed with brain death because of Apnea test positive and / or cranial reflexes were not available and were male and female patients aged 18-72 years

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Adult patients with definite diagnosis of brain death,
• Patients with permission from their parents,
• Patients without trauma of medullaspinalis and peripheral nerve injuries,
• Patients without previously known muscle disease (Myasthenia gravis, myopathy, etc.),
• Patients with previously unknown neurological disease (Amyotrophic Lateral Sclerosis, Multiple sclerosis, Guillain Barre syndrome, Poliomyelitis, etc.),
• Patients who have not previous systemic diseases (Connective Tissue Disease, Diabetes mellitus, Chronic renal failure, etc.).

Exclusion Criteria

• Uncertain brain death,
• Patients without permission of family members,
• Younger than 18 years old and older than 72 years,
• Patients with medulla spinalis and peripheral nerve injuries,
• Patients with known muscle disease (Myasthenia gravis, myopathy, etc.),
• Patients with neurological disease (Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Guillain Barre Syndrome, Poliomyelitis, etc.),
• Patients with previous systemic diseases (Connective Tissue Disease, Diabetes, Chronic Kidney Failure, etc.)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 72 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Yuzuncu Yıl University

OTHER

Sponsor Role: lead

Responsible Party

Hilmi Demirkiran, MD

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hilmi Demirkiran, MD

Role: STUDY_DIRECTOR

Department of Anethesiology and Reanimation

Aydin Cagac, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Neurology

Locations

Yuzuncu Yil University, School of Medicine

Van, Tusba / Zeve Kampus, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

EMG in Brain Death

Identifier Type: -

Identifier Source: org_study_id