Cerebral Autoregulation in Patients With Epilepsy

NCT ID: NCT02775682

Last Updated: 2021-08-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-30

Study Completion Date

2017-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether patients with epilepsy exhibiting impaired dCA, which may contribute to subsequent stroke.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The relationship between epileptic seizures and cerebrovascular disease is complex, ranging from mechanisms to clinical manifestation. Stroke is one of the most common causes of epilepsy in adulthood. It was also reported that patients with epilepsy exhibited a higher risk of stroke. But its potential mechanism was never fully understood. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral bold flow, has been proved to be critical for the occurrence ,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that impaired dCA play a role in epilepsy and subsequent stroke.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Epilepsy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

patients with epilepsy

No interventions assigned to this group

normal individuals without epilepsy

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients with epilepsy, as diagnosed by EEG

Exclusion Criteria

* patients with status epilepticus
* intracranial and/or extracranial major vascular stenosis/occlusion diagnosed by a transcranial Doppler (EMS-9PB, Delica, China) and carotid ultrasound (IU22, Phillips, Andover, MA)
* a prior symptomatic cerebral vascular disease
* a history of hypertension, cardiovascular disease, diabetes, hyperlipemia, current arrhythmia, hyperthyroidism, anemia and unstable blood pressure, which may undermine hemodynamic stability, or inability to cooperate sufficiently to complete the cerebral auto regulation examination
* insufficient bilateral temporal bone windows for insonation of the middle cerebral artery
* intolerance to cerebral autoregulation measurements
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Yi Yang

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Yi Yang

Associated Dean of First Hospital of Jilin University

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Yi Yang, MD,PhD

Role: STUDY_CHAIR

Neuroscience Center, Department of Neurology, The First Hospital of Jilin University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

First Hospital of Jilin University

Changchun, Jilin, China

Site Status

Countries

Review the countries where the study has at least one active or historical site.

China

References

Explore related publications, articles, or registry entries linked to this study.

Lv S, Guo ZN, Jin H, Sun X, Jia M, Ma H, Lv Y, Qiu Q, Liu J, Yang Y. Compromised Dynamic Cerebral Autoregulation in Patients with Epilepsy. Biomed Res Int. 2018 Feb 7;2018:6958476. doi: 10.1155/2018/6958476. eCollection 2018.

Reference Type DERIVED
PMID: 29568762 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CA&EEG

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Human Intracranial Electrophysiology
NCT05529264 RECRUITING NA
The Value of EEG in Stroke Units
NCT07190976 RECRUITING
Microelectrodes in Epilepsy
NCT05200455 COMPLETED NA