Recording High Frequency Oscillations in Patients With Tumors and Epilepsy

NCT ID: NCT02320136

Last Updated: 2023-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2025-12-31

Brief Summary

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The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation.

The investigators want to show that recording of high-frequency oscillations (HFOs) is feasible in our project population both intraoperatively and during presurgical physiological conditions.

Detailed Description

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Conditions

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Epilepsy Tumor

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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epilepsy

epilepsy patients

cognitive testing

Intervention Type BEHAVIORAL

patients perform simple tasks like watching a video or memorizing items

tumor with epilepsy

tumor patients with epileptic seizures

cognitive testing

Intervention Type BEHAVIORAL

patients perform simple tasks like watching a video or memorizing items

tumor without epilepsy

tumor patients without epileptic seizures

cognitive testing

Intervention Type BEHAVIORAL

patients perform simple tasks like watching a video or memorizing items

Interventions

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cognitive testing

patients perform simple tasks like watching a video or memorizing items

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Patients intend to be treated at the Klinik für Neurochirurgie
* Patients fall into one of the patient groups: (1) Patients with symptomatic epilepsy with focal and/or secondary generalized seizures resistant to medication where a neurosurgical resection is considered as an intervention of epilepsy surgery. (2)Patients where a tumor is planned to be resected that has caused preoperative seizures. (3) Patients where a tumor is planned to be resected that has not caused preoperative seizures.
* Male and Female subjects 18 years to 99 years of age
* Written informed consent after participants' information

Exclusion Criteria

* contraindications on ethical grounds
* known or suspected non-compliance, drug or alcohol abuse,
* enrolment into a clinical trial within last 4 weeks
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Zurich

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Johannes Sarnthein, Prof Dr

Role: PRINCIPAL_INVESTIGATOR

Universitätsspital Zürich

Other Identifiers

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HFO

Identifier Type: -

Identifier Source: org_study_id