Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules
NCT ID: NCT03257930
Last Updated: 2020-05-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
1 participants
INTERVENTIONAL
2017-08-11
2019-01-01
Brief Summary
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Detailed Description
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Goiter and the associated thyroid nodules result in anxiety, cosmetic disfigurement, and rarely compressive symptoms necessitating surgical removal, a procedure inherently associated with risks and complications Percutaneous sclerotherapy has been suggested to be an effective alternative, especially in patients with cystic nodules. Simple cystic (purely cystic) constitutes 6-28% of all thyroid nodules, are usually benign, filled with cellular debris or blood, and are a result of degeneration or hemorrhage into a hyperplastic nodule.
Among the various compounds (sodium tetradocyl sulfate, hydroxypolyethoxydodecan, tetracycline, and ethanol) tried for sclerosis of cystic thyroid nodules, outcomes are best and most studied with ethanol. However, data on outcomes of percutaneous aspiration and ethanol injection (PEI) in resolution of thyroid nodules is highly variable in different studies (success rate: 38-85%), which may be due to different populations studied and the heterogeneous nature of thyroid nodules evaluated.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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injection of ethanol
use of ethanol injection in the treatment of cystic thyroid nodule
ethanol injection
inject ethanol in cystic thyroid nodule and follow up until complete recovery
Interventions
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ethanol injection
inject ethanol in cystic thyroid nodule and follow up until complete recovery
Eligibility Criteria
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Inclusion Criteria
2. Presence of pressure symptoms or cosmetic problems
3. Benign lesions confirmed by histopathological examination by FNAC.
4. Serum levels of thyroid hormone thyrotropin, within normal limits.
Exclusion Criteria
2. solid thyroid nodule
3. mixed thyroid nodule(cystic with solid component)
15 Years
60 Years
ALL
Yes
Sponsors
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hassan harby mohamed
OTHER
Responsible Party
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hassan harby mohamed
general surgery
Locations
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Assiut University
Asyut, , Egypt
Countries
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References
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Vogel D, Durham AC, de Marcillac GD. Metastable aggregates in the polymerisation of tobacco-mosaic-virus protein. Eur J Biochem. 1977 Sep 15;79(1):161-71. doi: 10.1111/j.1432-1033.1977.tb11794.x. No abstract available.
Monzani F, Lippi F, Goletti O, Del Guerra P, Caraccio N, Lippolis PV, Baschieri L, Pinchera A. Percutaneous aspiration and ethanol sclerotherapy for thyroid cysts. J Clin Endocrinol Metab. 1994 Mar;78(3):800-2. doi: 10.1210/jcem.78.3.8126160.
Other Identifiers
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Ethanol Injection
Identifier Type: -
Identifier Source: org_study_id
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