Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
NCT ID: NCT03231241
Last Updated: 2025-07-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
700 participants
OBSERVATIONAL
2014-12-12
2026-09-01
Brief Summary
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Detailed Description
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Participation in this research study, will include online questionnaires, a blood sample, a lumbar puncture, and a magnetic resonance imaging (MRI) scan without contrast to measure brain activity. Participant may select to participate in a magnetic resonance imaging (MRI) scan and/ or lumbar puncture. participating in atleast 3 procedures is required (blood draw, online questionnaires , MRI and/or Spinal Tap.
The study recruits participants with headache ( any type of headaches), and patients with no headaches ( or less than 2/year). Participants do not need to have a specified headache type. All participants are asked to complete an on-line survey to characterize a number of phenotypic features felt to be relevant by the Investigators. Three independent study groups (imaging, proteomics/genetics, and phenotyping) analyze data independently and stratify the data. Then, by group analysis, correlation among the different modalities is sought to identify features that distinguish common elements that might help elucidate features that could predict which patients with episodic headache are likely to progress to chronic, and which patients without headache might be at greater risk to develop new daily persistent headache.
Conditions
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Study Design
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ECOLOGIC_OR_COMMUNITY
CROSS_SECTIONAL
Study Groups
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Episodic Headache
Participants experiencing headache of any type more than twice per year but less than 15 days per month. No interventions
No interventions assigned to this group
Chronic Headache
Participants experiencing headache more than 15 days per month for at least three consecutive months. No interventions
No interventions assigned to this group
Control
Participants reporting fewer than two headaches per year. No interventions
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Subject must be able to or at least with some help willing to complete online questionnaires in English .
* Willing to comply with study instructions.
* must speak and understand English
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Stanford University
OTHER
Responsible Party
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Robert Cowan
Director and Chief, Division of Headache Medicine
Principal Investigators
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Robert Cowan, MD, FAAN
Role: PRINCIPAL_INVESTIGATOR
Stanford University
Locations
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Stanford University School of Medicine
Stanford, California, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Woldeamanuel YW, Sanjanwala BM, Cowan RP. Deep and unbiased proteomics, pathway enrichment analysis, and protein-protein interaction of biomarker signatures in migraine. Ther Adv Chronic Dis. 2024 Sep 18;15:20406223241274302. doi: 10.1177/20406223241274302. eCollection 2024.
Other Identifiers
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SunStar
Identifier Type: -
Identifier Source: org_study_id
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