Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2016-08-31

Brief Summary

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The occipital nerve stimulation (ONS) is used to treat patients with refractory primary chronic headache but its mechanism of action (MoA) remains unknown. Different hypothesis have been suggested in particular a specific action on cerebral generators involved in different types of primary headaches or a non specific action on pain modulatory network.

The aim of this study, using the chronic cluster headache as a model, is to determine the changes in cerebral metabolism induced by ONS to precise its MoA in the treatment of primary chronic headache.

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Detailed Description

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Conditions

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Refractory Chronic Cluster Headache

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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subjects with refractory chronic cluster headache

Adult subjects with refractory chronic cluster headache and ONS indication

Group Type EXPERIMENTAL

18F-FDG PET

Intervention Type RADIATION

Interventions

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18F-FDG PET

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* age \> 18 years
* chronic cluster headache (according to the IHS)
* refractory in who a treatment by ONS have been indicated
* patient affiliated at social security,
* informed consent signed

Exclusion Criteria

* contraindication to MRI
* contraindication to 18F-FDG PET
* women without contraception/pregnant/breast-feeding
* patient non-compliant
* patient on legal guardianship

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No