Intraoperative Pleth Variability Index (PVI) Variability

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-10-01

Study Completion Date

2018-11-30

Brief Summary

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Pleth Variability Index (PVI) is a variable that is derived from photoplethysmography (PPG) signal. It is used as a surrogate for intravascular volume status intraoperatively. PVI can have significant amount of baseline variability which appears to oscillate at a very low frequency (5-10 minute cycles). This study aims to investigate the origin of these baseline oscillations.

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Detailed Description

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PVI is derived from the infrared photoplethysmography signal. Intraoperatively during mechanical ventilation it reflect fluid responsiveness which is a surrogate endpoint of intravascular volume.

PVI signal appears to have significant baseline variability which can not be explained by rapid changes in intravascular fluid volume. The baseline PVI changes also appear to oscillate at a very low frequency, much below any previously identified spontaneous vascular oscillations.

The aim of this study is to investigate weather the PVI variability originates from changes in the infrared photoplethysmography signal or if they are possibly due to the algorithm calculating PVI.

Conditions

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Intraoperative Monitoring

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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neurosurgical patients

Neurosurgical patients undergoing craniotomies for tumor. 25 subjects

No interventions assigned to this group

Neurointerventional patients

Patients undergoing neurointerventional procedures under general anesthesia. 25 subjects

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Neurosurgical patients for tumor resection
* neurointerventional patients
* general anesthesia with mechanical ventilation
* communicates in english (consent)
* over 18 years of age