Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
236 participants
OBSERVATIONAL
2018-04-28
2019-07-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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HSP patients
Patients with hereditary spastic paraplegia regardless of their genetic mutation
EuroQol five dimensions questionaire (EQ-5D)
Testing quality of life.
Modified Fatigue Impact Scale (MFI)
Screening for fatigue
Brief Pain Inventory (BPI)
Testing for pain
Becks Depression Inventory (BDI)
Screening for depression
Restless-leg Questionaire (RLS diagnostic criteria)
Testing for restless-legs
Healthy controls
healthy controls (spouses, relatives, or other healthy controls)
EuroQol five dimensions questionaire (EQ-5D)
Testing quality of life.
Modified Fatigue Impact Scale (MFI)
Screening for fatigue
Brief Pain Inventory (BPI)
Testing for pain
Becks Depression Inventory (BDI)
Screening for depression
Restless-leg Questionaire (RLS diagnostic criteria)
Testing for restless-legs
Interventions
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EuroQol five dimensions questionaire (EQ-5D)
Testing quality of life.
Modified Fatigue Impact Scale (MFI)
Screening for fatigue
Brief Pain Inventory (BPI)
Testing for pain
Becks Depression Inventory (BDI)
Screening for depression
Restless-leg Questionaire (RLS diagnostic criteria)
Testing for restless-legs
Eligibility Criteria
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Inclusion Criteria
* Group 2: Healthy controls
* Age 18 to 70 years
* Written, informed consent
Exclusion Criteria
* Presence of spastic gait disorder or other neurological condition (Group 2)
18 Years
70 Years
ALL
No
Sponsors
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University Hospital Tuebingen
OTHER
Responsible Party
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Dr. Tim W. Rattay
Assistant doctor and postdoctoral researcher
Principal Investigators
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Tim W. Rattay, MD
Role: PRINCIPAL_INVESTIGATOR
Researcher
Locations
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University Hospital Tübingen, Center for Neurology
Tübingen, , Germany
Countries
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References
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Rattay TW, Boldt A, Volker M, Wiethoff S, Hengel H, Schule R, Schols L. Non-motor symptoms are relevant and possibly treatable in hereditary spastic paraplegia type 4 (SPG4). J Neurol. 2020 Feb;267(2):369-379. doi: 10.1007/s00415-019-09573-w. Epub 2019 Oct 23.
Related Links
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Link Citation (DOI)
Other Identifiers
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NMS in HSP
Identifier Type: -
Identifier Source: org_study_id
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