The Complex Regional Pain Syndrome (CRPS) is a Chronic Pain Condition. This is a Preliminary Study to Explore and Test Clinical Hypothesis. They Suppose That CRPS Patients Have Impairment in Their Mental or Motor Imagery Abilities.

NCT ID: NCT04703348

Last Updated: 2025-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

129 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-12

Study Completion Date

2022-10-30

Brief Summary

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Medical functional imagery seems to demonstrate that patients suffering from complex regional pain syndrome (CRPS) have cortical modifications that alter their motor (or mental) imagery capacities. Nowadays, the use of motor imagery exercises are used in conventional rehabilitation treatments. But, in clinical practice, no study has verified if patients with CRPS desmonstrate problems in their motor imagery capacities. The MIQ-RS (Motor Imagery Questionnaire - Revised Second) is a valid, reliable and translated into French questionnaire to measure patients' capacities to do mental imagery. In this study, we compare 3 groups of 50 patients : healthy patients, patients with CRPS and patients with musculoskeletal disorder without CRPS. Every patient will take the MIQ-RS for the right and left body side. We hypothesis that patients with CRPS have more deficit than the 2 others to realise motor imagery.

Detailed Description

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Conditions

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Complex Regional Pain Syndromes Musculoskeletal Pain Disorder Healthy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

3 groups with different healthcare conditions are compared in motor imagery capacities
Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Healthy patients

Healthy patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side

Group Type OTHER

Motor imagery Questionnaire - Revised Second (MIQ-RS)

Intervention Type DIAGNOSTIC_TEST

Patients fulfill a questionnaire measuring individuals capacities to realize mental imagery. For more facilities and less risk of bias, the MIQ-RS was written on an online version with questions recorded in audio format. No official cut-off exists but studies seem to prove that people with :

* a score less than 48/98 are unable to do motor imagery
* a score between 49 and 73/98 have disturbed motor imagery capacities
* a score more than 74/98 have normal motor imagery capacities.

Complex regional pain syndrome patients

Complex regional pain syndrome patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side

Group Type OTHER

Motor imagery Questionnaire - Revised Second (MIQ-RS)

Intervention Type DIAGNOSTIC_TEST

Patients fulfill a questionnaire measuring individuals capacities to realize mental imagery. For more facilities and less risk of bias, the MIQ-RS was written on an online version with questions recorded in audio format. No official cut-off exists but studies seem to prove that people with :

* a score less than 48/98 are unable to do motor imagery
* a score between 49 and 73/98 have disturbed motor imagery capacities
* a score more than 74/98 have normal motor imagery capacities.

Musculoskelettal disorders patients

Musculoskelettal disorders patients take the MIQ-RS during about 40 minutes : about 20 minutes for the assessment of the right side and about 20 minutes for the left side

Group Type OTHER

Motor imagery Questionnaire - Revised Second (MIQ-RS)

Intervention Type DIAGNOSTIC_TEST

Patients fulfill a questionnaire measuring individuals capacities to realize mental imagery. For more facilities and less risk of bias, the MIQ-RS was written on an online version with questions recorded in audio format. No official cut-off exists but studies seem to prove that people with :

* a score less than 48/98 are unable to do motor imagery
* a score between 49 and 73/98 have disturbed motor imagery capacities
* a score more than 74/98 have normal motor imagery capacities.

Interventions

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Motor imagery Questionnaire - Revised Second (MIQ-RS)

Patients fulfill a questionnaire measuring individuals capacities to realize mental imagery. For more facilities and less risk of bias, the MIQ-RS was written on an online version with questions recorded in audio format. No official cut-off exists but studies seem to prove that people with :

* a score less than 48/98 are unable to do motor imagery
* a score between 49 and 73/98 have disturbed motor imagery capacities
* a score more than 74/98 have normal motor imagery capacities.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patient with French healthcare affiliation
* Adult patient (\> 18 years old)
* Patient with bachelor degree minimum
* Patient practicing less than 150 minutes of moderate to intense physical activity per week


* Patient followed in the Evaluation and Treatment pain center (University Hospital of Nimes)
* Patient with secondary CRPS due to a traumatism or a surgery


* Patient with musculoskelettal disorder on a limb (upper or lower)
* Patient followed in the University Hospital of Nimes


* Patient who participates in another category 1 research
* Patient in a exclusion period in another study
* Patient under legal protection, under guardianship or under curatorship
* Patient for whom it is impossible to give clear information.
* Pregnant, parturient or breastfeeding patient.
* Patient with amputation on one of his limb
* Patient with visual cecity
* Patient who has already practiced mental imagery
* Patient with neurological impairment
* Patient with chronic low back pain and fibromyalgia


-Patient with CRPS


* Secondary CRPS to CVA (cerebrovascular accident)
* Patient receiving lymph node block treatment between the inclusion visit and the follow-up visit


* Patient with secondary musculoskeletal disorder to a CVA

Exclusion Criteria

* Questionnaire MIQ-RS not completed or non respect with the research protocol
* pathology discovered incompatible with the study criteria
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU de Nimes

Nîmes, Gard, France

Site Status

Countries

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France

References

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Cohen-Aknine G, Mottet D, Homs AF, Mura T, Jedryka F, Dupeyron AF. Explicit Motor Imaging Abilities Are Similar in Complex Regional Pain Syndrome, Chronic Limb Pain and Healthy Individuals: A Cross-Sectional Study. J Pain Res. 2025 Apr 11;18:1949-1961. doi: 10.2147/JPR.S494546. eCollection 2025.

Reference Type RESULT
PMID: 40236719 (View on PubMed)

Related Links

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Other Identifiers

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2020-A02281-38

Identifier Type: OTHER

Identifier Source: secondary_id

LOCAL/2020/MO-01

Identifier Type: -

Identifier Source: org_study_id

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