Transthoracic Sonography Versus High Resolution Computed Tomography in Alveolar Intersitial Syndrome

NCT ID: NCT03172585

Last Updated: 2017-06-01

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 1 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-06-30
• Study Completion Date: 2018-08-31

Brief Summary

High resolution computed tomography of the chest is the gold standard imaging modality for most pulmonary diseases. However, the associated high expenses, radiation exposure , and its limited possibility for bedside use are a limitation.

Detailed Description

High resolution computed tomography of the chest is the gold standard imaging modality for most pulmonary diseases. However, the associated high expenses, radiation exposure , and its limited possibility for bedside use are a limitation. Transthoracic ultrasonograghy is used progressively for evaluation of pulmonary diseases. Its non invasive nature , relatively low price ,portability for bedside use, and high reproducibility of results allows for incorporation of imaging findings with clinical data. Although Transthoracic ultrasonograghy is not an alternative to High resolution computed tomography,it can potentially provide useful supplemental information in certain specific situations ,such as for rapid bedside diagnostic assessment of dyspneic patients. B-line is a common and significant abnormal sign used for diagnostic appraisal by Transthoracic ultrasonograghy, but it cannot define the exact underlying pathologic feature on a lung ultrasound. When the lung parenchymal pathology reaches the lung surface ,certain characteristic changes of the pleural line can be detected by means of the good imaging made possible by high-resolution Transthoracic ultrasonograghy ,but the application and strength of pleural line abnormalities in the differential diagnosis of lung diseases has not been adequately explored . Existing literature on the illustration of the pleural line is scarce ,and the shape of pleural line has not been adequately investigated and described ,especially in comparison with Computed tomography findings. Most studies that have investigated pleural lines are confined to the sub population with interstitial lung diseases.

Conditions

Pleural Diseases

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

High Resolution computed tomography

Patients will be included in the study when High resolution chest computed tomography without contrast enhancement is ordered by the primary physician. Before the High resolution chest computed tomography scan, a Trans thoracic ultrasonography will be performed.

Group Type: OTHER

High resolution computed tomography

Intervention Type: OTHER

High resolution computed tomography of the chest is the gold standard imaging modality for most pulmonary diseases

trans thoracic ultrasonography

Intervention Type: OTHER

Trans thoracic ultrasonograghy is used progressively for evaluation of pulmonary diseases . Its non invasive nature , relatively low price ,portability for bedside use, and high reproducible of results allows for incorporation of imaging findings with clinical data

Interventions

High resolution computed tomography

High resolution computed tomography of the chest is the gold standard imaging modality for most pulmonary diseases

Intervention Type: OTHER

trans thoracic ultrasonography

Trans thoracic ultrasonograghy is used progressively for evaluation of pulmonary diseases . Its non invasive nature , relatively low price ,portability for bedside use, and high reproducible of results allows for incorporation of imaging findings with clinical data

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Patients presenting with dyspnea due to interstitial fibrosis syndrome.

2. pulmonary edema due to any cause.

Exclusion Criteria

1. Traumatic lesions

2. Pneumothorax

3. Subcutaneous emphysema

4. Massive pleural effusion with atelectasis, and

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

mariam hany adeeb

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Manal Mohamed, MD

Role: STUDY_DIRECTOR

Assiut University

Central Contacts

Gamal Rabeea, MD

Role: CONTACT

gamalagmy135@gmail.com

00201221729476

Mohamed Fawzy, MD

Role: CONTACT

mohamedadam200010@yahoo.com

00201003032335

References

Sartori S, Tombesi P. Emerging roles for transthoracic ultrasonography in pleuropulmonary pathology. World J Radiol. 2010 Feb 28;2(2):83-90. doi: 10.4329/wjr.v2.i2.83.

Reference Type: BACKGROUND

PMID: 21160921 (View on PubMed)

Frenz MB, Mee AS. Diagnostic radiation exposure and cancer risk. Gut. 2005 Jun;54(6):889-90. doi: 10.1136/gut.2005.066605. No abstract available.

Reference Type: BACKGROUND

PMID: 15888804 (View on PubMed)

Volpicelli G, Mussa A, Garofalo G, Cardinale L, Casoli G, Perotto F, Fava C, Frascisco M. Bedside lung ultrasound in the assessment of alveolar-interstitial syndrome. Am J Emerg Med. 2006 Oct;24(6):689-96. doi: 10.1016/j.ajem.2006.02.013.

Reference Type: BACKGROUND

PMID: 16984837 (View on PubMed)

Smargiassi A, Inchingolo R, Soldati G, Copetti R, Marchetti G, Zanforlin A, Giannuzzi R, Testa A, Nardini S, Valente S. The role of chest ultrasonography in the management of respiratory diseases: document II. Multidiscip Respir Med. 2013 Aug 9;8(1):55. doi: 10.1186/2049-6958-8-55.

Reference Type: BACKGROUND

PMID: 23937897 (View on PubMed)

Leech M, Bissett B, Kot M, Ntoumenopoulos G. Lung ultrasound for critical care physiotherapists: a narrative review. Physiother Res Int. 2015 Jun;20(2):69-76. doi: 10.1002/pri.1607. Epub 2014 Dec 29.

Reference Type: BACKGROUND

PMID: 25545613 (View on PubMed)

Lichtenstein D, Meziere G, Biderman P, Gepner A, Barre O. The comet-tail artifact. An ultrasound sign of alveolar-interstitial syndrome. Am J Respir Crit Care Med. 1997 Nov;156(5):1640-6. doi: 10.1164/ajrccm.156.5.96-07096.

Reference Type: BACKGROUND

PMID: 9372688 (View on PubMed)

Other Identifiers

AIS

Identifier Type: -

Identifier Source: org_study_id