Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-28

Study Completion Date

2025-12-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Alveoscopy, Endoscopic Confocal Microscopy and Lung Rejection, Parenchymal Lung Diseases in Vivo

NCT01033201

Lung Transplant

COMPLETED

Study of Transbronchial Cryobiopsy in Monitoring Complications of Lung Transplantation

NCT05792384

Lung Transplant Rejection

UNKNOWN NA

Determination of Pneumothorax Post Lung Biopsy

NCT02840032

Pneumothorax

WITHDRAWN

Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation

NCT00528853

Bronchiolitis Obliterans Syndrome

COMPLETED

Transbronchial Lung Cryobiopsy in Undiagnosed Acute Respiratory Failure

NCT05754866

Acute Respiratory Failure Acute Respiratory Distress Syndrome

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Lung transplant recipients are at high risk for lung rejection and lung infection after transplant. This is diagnosed by performing lung bronchoscopies and lung biopsies. These procedures carry an increased risk for complications and are costly. This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Post-Lung Transplantation Bronchiectasis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

There is only 1 group of participants being monitored. Every patient will follow the same study procedures

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

This study is not blinded

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Receiving Ultrasound

Every patient will receive a lung ultrasound prior to each scheduled bronchoscopy until the study stops.

Group Type EXPERIMENTAL

Lung ultrasound

Intervention Type DIAGNOSTIC_TEST

The lung ultrasound will be performed by a trained pulmonologist by gently pressing a probe to various areas of your chest. This is a non-invasive procedure and you should not feel any pain. The ultrasound will take less than 10 minutes.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Lung ultrasound

The lung ultrasound will be performed by a trained pulmonologist by gently pressing a probe to various areas of your chest. This is a non-invasive procedure and you should not feel any pain. The ultrasound will take less than 10 minutes.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients (\> 18 yrs) who had undergone single/double/heart-lung transplant
* Asymptomatic
* Normal spirometry defined as a FEV1 without significant drop from baseline (significant drop = \>10% decrease from baseline)
* Clear chest radiograph over allograft

Exclusion Criteria

* Patients who are unable to consent for the procedure
* Patients with subcutaneous emphysema or other technical challenges that could interfere with satisfactory image acquisition- as deemed by the operator.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes