Correlation Between Quantitative Analysis of Coronary MRA and FFR

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

89 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-07-01

Study Completion Date

2018-05-31

Brief Summary

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This study aims to evaluate whether quantitative analysis of coronary MR angiogram would improve the detection of functionally-significant coronary artery stenosis.

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Detailed Description

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Coronary MR angiography is performed with a 3.0-T imager with 32-channel coils. Qunatitative analysis of coronary MR angiogram is evaluated on the basis of the signal intensity (SI) profile along the vessel. Quantitative analysis of coronary MR angiogram (QCMRA) is calculated as \[1 - (SImin/SIref)\] x 100, where SImin is minimal SI and SIref is corresponding reference SI. Diagnostic performance of quantitative analysis of coronary MR angiogram for predicting functional significant coronary stenosis was evaluated by using fractional flow reserve (FFR) as the reference standard.

Conditions

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Coronary Artery Disease Magnetic Resonance Angiography Fractional Flow Reserve

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Coronary MR angiography

Quantitative analysis of coronary MR angiogram

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* 1 or more coronary stenoses in the major coronary artery with a vessel diameter ≥ 2mm on coronary MR angiogram
* Patient who were planned to undergo invasive coronary angiography and fractional flow reserve

Exclusion Criteria

* clinically unstable patient
* a history of coronary revascularization
* infiltrative cardiomyopathy, hypertropic cardiomyopathy, myocarditis
* contraindication to use of adenosine
* complete occlusion of target lesion

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No