Brain Protection Effect of Selective Head Cooling and Dexmedetomidine in Patients Undergoing Liver Transplantation
NCT ID: NCT03102359
Last Updated: 2019-05-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
100 participants
INTERVENTIONAL
2017-04-05
2019-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Selective Head Cooling
Participants received a cooling helmet filled with ice water mixture after an-esthesia induction until the end of the surgery.
Cooling Helmet
Using cooling helmet for selective head cooling group and Selective Head Cooling and Dexmedetomidine group
Dexmedetomidine
Giving dexmedetomidine1μg/kg i.v for 10 minutes, then use computerized infusion pump at 0.5μg/kg.h until the end of the surgery.
Dexmedetomidine
Using dexmedetomidine at anesthesia induction and maintain until the end of the surgery
Selective Head Cooling and Dexmedetomidine
Using selective head cooling combined with dexmedetomidine as described before
Dexmedetomidine
Using dexmedetomidine at anesthesia induction and maintain until the end of the surgery
Cooling Helmet
Using cooling helmet for selective head cooling group and Selective Head Cooling and Dexmedetomidine group
Control
No intervention in this group
No interventions assigned to this group
Interventions
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Dexmedetomidine
Using dexmedetomidine at anesthesia induction and maintain until the end of the surgery
Cooling Helmet
Using cooling helmet for selective head cooling group and Selective Head Cooling and Dexmedetomidine group
Eligibility Criteria
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Inclusion Criteria
* Sign the informed consent
Exclusion Criteria
* Patients diagnosed with hepatic encephalopathy or had a low Mini-Mental State Examination (MMSE) score (below 24) preoperatively.
* With concurrent diseases such as renal insufficiency, diabetes mellitus were also excluded.
* Patients were excluded if severe reperfusion syn-drome (mean arterial pressure below 60mmHg sustained over 15minutes) occurred perioperatively.
18 Years
65 Years
ALL
No
Sponsors
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Huazhong University of Science and Technology
OTHER
Responsible Party
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Huawei He
Postgraduate
Locations
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Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology
Wuhan, Hubei, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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TJ-IRB20170201
Identifier Type: -
Identifier Source: org_study_id
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