Dexmedetomidine Improves Recovery After Cranial Aneurysm Surgery
NCT ID: NCT03355534
Last Updated: 2022-05-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
150 participants
INTERVENTIONAL
2018-01-05
2020-12-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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nasal dexmedetomidine
dexmedetomidine is given nasally, saline is given intravenously
nasal dexmedetomidine
drug is nasally given to patients
intravenous saline
saline is given to patients intravenously
intravenous dexmedetomidine
saline is given nasally, dexmedetomidine is given intravenously
Intravenous dexmedetomidine
drug is intravenously infused to patients
nasal saline
normal saline is given to patients nasally
normal saline
saline is given nasally and intravenously
intravenous saline
saline is given to patients intravenously
nasal saline
normal saline is given to patients nasally
Interventions
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Intravenous dexmedetomidine
drug is intravenously infused to patients
nasal dexmedetomidine
drug is nasally given to patients
intravenous saline
saline is given to patients intravenously
nasal saline
normal saline is given to patients nasally
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* patients with ASA(American Society of Anesthesiologists) status over 3
* patients with body mass index(BMI)≥30kg/m2
* patients with difficulty in communication
* patients with ruptured aneurysm
* patients suspected or proved to be pregnant
18 Years
65 Years
ALL
No
Sponsors
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Zhihong LU
OTHER
Responsible Party
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Zhihong LU
clinical professor
Principal Investigators
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Lize Xiong
Role: STUDY_CHAIR
Air Force Military Medical University, China
Locations
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Xijing Hospital
Xi'an, Shaanxi, China
Countries
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References
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Peng K, Wu S, Liu H, Ji F. Dexmedetomidine as an anesthetic adjuvant for intracranial procedures: meta-analysis of randomized controlled trials. J Clin Neurosci. 2014 Nov;21(11):1951-8. doi: 10.1016/j.jocn.2014.02.023. Epub 2014 Jun 25.
Soliman RN, Hassan AR, Rashwan AM, Omar AM. Prospective, randomized controlled study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anesthesia. Middle East J Anaesthesiol. 2011 Feb;21(1):23-33.
Elbakry AE, Ibrahim E. Propofol-dexmedetomidine versus propofol-remifentanil conscious sedation for awake craniotomy during epilepsy surgery. Minerva Anestesiol. 2017 Dec;83(12):1248-1254. doi: 10.23736/S0375-9393.17.11873-0. Epub 2017 Jun 14.
Jun JH, Kim KN, Kim JY, Song SM. The effects of intranasal dexmedetomidine premedication in children: a systematic review and meta-analysis. Can J Anaesth. 2017 Sep;64(9):947-961. doi: 10.1007/s12630-017-0917-x. Epub 2017 Jun 21.
Sun Y, Li Y, Sun Y, Wang X, Ye H, Yuan X. Dexmedetomidine Effect on Emergence Agitation and Delirium in Children Undergoing Laparoscopic Hernia Repair: a Preliminary Study. J Int Med Res. 2017 Jun;45(3):973-983. doi: 10.1177/0300060517699467. Epub 2017 Mar 21.
Other Identifiers
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XJH-A-2017-10-10
Identifier Type: -
Identifier Source: org_study_id
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